Hydroxyquinoline-derived compounds and analoguing of selective Mcl-1 inhibitors using a functional biomarker.

Richard, David J; Lena, Ryan; Bannister, Thomas; Blake, Noel; Pierceall, William E; Carlson, Nicole E; Keller, Christina Eberhart; Koenig, Marcel; He, Yuanjun; Minond, Dmitriy; Mishra, Jitendra; Cameron, Michael; Spicer, Timothy; Hodder, Peter; Cardone, Michael H

Richard, David J; Lena, Ryan; Bannister, Thomas; Blake, Noel; Pierceall, William E; Carlson, Nicole E; Keller, Christina Eberhart; Koenig, Marcel; He, Yuanjun; Minond, Dmitriy; Mishra, Jitendra; Cameron, Michael; Spicer, Timothy; Hodder, Peter; Cardone, Michael H.

Affiliation

Richard DJ; Eutropics Pharmaceuticals, 767C Concord Avenue, Cambridge, MA 02138, United States.

Bioorg Med Chem ; 21(21): 6642-9, 2013 Nov 01.

Article in En | MEDLINE | ID: mdl-23993674

Subject(s)

Hydroxyquinolines/chemistry; Myeloid Cell Leukemia Sequence 1 Protein/antagonists & inhibitors; Piperazines/chemistry; Animals; Antineoplastic Agents/chemical synthesis; Antineoplastic Agents/chemistry; Antineoplastic Agents/toxicity; Apoptosis/drug effects; Binding Sites; Biomarkers/metabolism; Cell Line, Tumor; Cytochromes c/metabolism; HL-60 Cells; High-Throughput Screening Assays; Humans; Hydroxyquinolines/chemical synthesis; Hydroxyquinolines/toxicity; Mice; Myeloid Cell Leukemia Sequence 1 Protein/metabolism; Piperazines/chemical synthesis; Piperazines/toxicity; Protein Structure, Tertiary; Proto-Oncogene Proteins c-bcl-2/antagonists & inhibitors; Proto-Oncogene Proteins c-bcl-2/metabolism; bcl-X Protein/antagonists & inhibitors; bcl-X Protein/metabolism

Key words

Apoptosis; Biomarkers; Cell-based activity; Mcl-1; Oncology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Myeloid Cell Leukemia Sequence 1 Protein / Hydroxyquinolines Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Journal subject: BIOQUIMICA / QUIMICA Year: 2013 Type: Article Affiliation country: United States

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