[Ultrastructure of the tumor cell lines treated with tumor necrosis factor].
Zhonghua Zhong Liu Za Zhi
; 12(2): 89-91, 1990 Mar.
Article
in Zh
| MEDLINE
| ID: mdl-2401183
ABSTRACT
The cytotoxic effect of purified tumor necrosis factor (TNF) derived from rabbit treated with BCG-LPS on tumor cell lines was studied by electron microscopy. Tumor cell lines L929, CNE-2 (poorly-differentiated carcinoma of nasopharynx) and Pc84045 (adenocarcinoma of lung) were treated in vitro with TNF. It was found that the membrane of the target cells still remained intact, while the cytoplasmic organellae, especially the mitochondria were destroyed. The mechanism of TNF cytotoxic activity is discussed.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Adenocarcinoma
/
Nasopharyngeal Neoplasms
/
Tumor Necrosis Factor-alpha
/
Lung Neoplasms
Limits:
Animals
/
Female
/
Humans
Language:
Zh
Journal:
Zhonghua Zhong Liu Za Zhi
Year:
1990
Type:
Article