Fatty acid labeling from glutamine in hypoxia can be explained by isotope exchange without net reductive isocitrate dehydrogenase (IDH) flux.

Fan, Jing; Kamphorst, Jurre J; Rabinowitz, Joshua D; Shlomi, Tomer

Fan, Jing; Kamphorst, Jurre J; Rabinowitz, Joshua D; Shlomi, Tomer.

Affiliation

Fan J; From the Lewis-Sigler Institute for Integrative Genomics and.

J Biol Chem ; 288(43): 31363-9, 2013 Oct 25.

Article in En | MEDLINE | ID: mdl-24030823

Subject(s)

Fatty Acids/metabolism; Glutamine/metabolism; Isocitrate Dehydrogenase/metabolism; Acetyl Coenzyme A/metabolism; Cell Hypoxia; Cell Line, Tumor; Fatty Acids/chemistry; Glutamine/chemistry; Humans; Isocitrate Dehydrogenase/chemistry; Ketoglutaric Acids/metabolism; Oxidation-Reduction

Key words

Cancer; Hypoxia; Isotopic Tracers; Metabolism; Mitochondrial Metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Fatty Acids / Glutamine / Isocitrate Dehydrogenase Limits: Humans Language: En Journal: J Biol Chem Year: 2013 Type: Article

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