Digitoxin sensitizes glioma cells to TRAIL-mediated apoptosis by upregulation of death receptor 5 and downregulation of survivin.

Lee, Dae-Hee; Lee, Chang Sup; Kim, Dong-Wook; Ae, Jeh Eun; Lee, Tae-Hwa

Lee, Dae-Hee; Lee, Chang Sup; Kim, Dong-Wook; Ae, Jeh Eun; Lee, Tae-Hwa.

Affiliation

Lee DH; aDepartment of Neurosurgery, School of Medicine bDepartment of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia, USA cDepartment of Obstetrics and Gynecology, College of Medicine, Kosin University, Korea.

Anticancer Drugs ; 25(1): 44-52, 2014 Jan.

Article in En | MEDLINE | ID: mdl-24045365

Subject(s)

Apoptosis/drug effects; Brain Neoplasms/drug therapy; Digitoxin/therapeutic use; Glioblastoma/drug therapy; Inhibitor of Apoptosis Proteins/metabolism; Receptors, TNF-Related Apoptosis-Inducing Ligand/metabolism; TNF-Related Apoptosis-Inducing Ligand/metabolism; Caspases, Effector/metabolism; Caspases, Initiator/metabolism; Cell Line, Tumor/drug effects; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Activation; Humans; Inhibitor of Apoptosis Proteins/genetics; RNA, Small Interfering/genetics; Receptors, TNF-Related Apoptosis-Inducing Ligand/genetics; Survivin; Up-Regulation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain Neoplasms / Apoptosis / Glioblastoma / Digitoxin / Inhibitor of Apoptosis Proteins / TNF-Related Apoptosis-Inducing Ligand / Receptors, TNF-Related Apoptosis-Inducing Ligand Limits: Humans Language: En Journal: Anticancer Drugs Journal subject: ANTINEOPLASICOS Year: 2014 Type: Article

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