Effect of nitric oxide on the anticancer activity of the topoisomerase-active drugs etoposide and adriamycin in human melanoma cells.

Sinha, Birandra K; Kumar, Ashutosh; Bhattacharjee, Suchandra; Espey, Michael G; Mason, Ronald P

Sinha, Birandra K; Kumar, Ashutosh; Bhattacharjee, Suchandra; Espey, Michael G; Mason, Ronald P.

Affiliation

Sinha BK; Laboratory of Toxicology and Pharmacology, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina (B.K.S., A.K., S.B., R.P.M.); and National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland (M.G.E.).

J Pharmacol Exp Ther ; 347(3): 607-14, 2013 Dec.

Article in En | MEDLINE | ID: mdl-24049059

Subject(s)

Antibiotics, Antineoplastic/pharmacology; Antineoplastic Agents, Phytogenic/pharmacology; Antineoplastic Agents/pharmacology; DNA Topoisomerases/drug effects; Doxorubicin/pharmacology; Etoposide/pharmacology; Melanoma/drug therapy; Nitric Oxide/pharmacology; Blotting, Western; Caspase 3/metabolism; Cell Line, Tumor; Cell Survival; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors/pharmacology; Humans; Lysine/analogs & derivatives; Lysine/pharmacology; Macrophages/drug effects; Nitric Oxide Synthase/antagonists & inhibitors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Doxorubicin / DNA Topoisomerases / Etoposide / Melanoma / Antibiotics, Antineoplastic / Antineoplastic Agents / Nitric Oxide / Antineoplastic Agents, Phytogenic Limits: Humans Language: En Journal: J Pharmacol Exp Ther Year: 2013 Type: Article

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