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The allosteric mechanism of activation of antithrombin as an inhibitor of factor IXa and factor Xa: heparin-independent full activation through mutations adjacent to helix D.
Dementiev, Alexey; Swanson, Richard; Roth, Ryan; Isetti, Giulia; Izaguirre, Gonzalo; Olson, Steven T; Gettins, Peter G W.
Affiliation
  • Dementiev A; Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois 60607.
  • Swanson R; Center for Molecular Biology of Oral Disease, University of Illinois at Chicago, Chicago, Illinois 60607.
  • Roth R; Center for Molecular Biology of Oral Disease, University of Illinois at Chicago, Chicago, Illinois 60607.
  • Isetti G; Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois 60607.
  • Izaguirre G; Center for Molecular Biology of Oral Disease, University of Illinois at Chicago, Chicago, Illinois 60607.
  • Olson ST; Center for Molecular Biology of Oral Disease, University of Illinois at Chicago, Chicago, Illinois 60607.
  • Gettins PGW; Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois 60607. Electronic address: pgettins@uic.edu.
J Biol Chem ; 288(47): 33611-33619, 2013 Nov 22.
Article in En | MEDLINE | ID: mdl-24068708
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Factor IXa / Factor Xa / Antithrombin III / Mutation Limits: Humans Language: En Journal: J Biol Chem Year: 2013 Type: Article
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Factor IXa / Factor Xa / Antithrombin III / Mutation Limits: Humans Language: En Journal: J Biol Chem Year: 2013 Type: Article