WNT/ß-catenin signalling is activated in aldosterone-producing adenomas and controls aldosterone production.

Berthon, Annabel; Drelon, Coralie; Ragazzon, Bruno; Boulkroun, Sheerazed; Tissier, Frédérique; Amar, Laurence; Samson-Couterie, Benoît; Zennaro, Maria-Christina; Plouin, Pierre-François; Skah, Seham; Plateroti, Michelina; Lefèbvre, Hervé; Sahut-Barnola, Isabelle; Batisse-Lignier, Marie; Assié, Guillaume; Lefrançois-Martinez, Anne-Marie; Bertherat, Jérôme; Martinez, Antoine; Val, Pierre

Berthon, Annabel; Drelon, Coralie; Ragazzon, Bruno; Boulkroun, Sheerazed; Tissier, Frédérique; Amar, Laurence; Samson-Couterie, Benoît; Zennaro, Maria-Christina; Plouin, Pierre-François; Skah, Seham; Plateroti, Michelina; Lefèbvre, Hervé; Sahut-Barnola, Isabelle; Batisse-Lignier, Marie; Assié, Guillaume; Lefrançois-Martinez, Anne-Marie; Bertherat, Jérôme; Martinez, Antoine; Val, Pierre.

Affiliation

Berthon A; Clermont Université, Université Blaise Pascal, GReD, BP 10448, F-63000 Clermont-Ferrand, France.

Hum Mol Genet ; 23(4): 889-905, 2014 Feb 15.

Article in En | MEDLINE | ID: mdl-24087794

Subject(s)

Adrenal Cortex Neoplasms/metabolism; Adrenocortical Adenoma/metabolism; Aldosterone/biosynthesis; Hyperaldosteronism/metabolism; Wnt Signaling Pathway; Adrenal Cortex Neoplasms/complications; Adrenocortical Adenoma/complications; Adult; Aldosterone/blood; Aldosterone/metabolism; Animals; Cell Line, Tumor; Cytochrome P-450 CYP11B2/genetics; Cytochrome P-450 CYP11B2/metabolism; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Humans; Hyperaldosteronism/etiology; Male; Membrane Proteins/genetics; Membrane Proteins/metabolism; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Middle Aged; Nuclear Receptor Subfamily 4, Group A, Member 1/genetics; Nuclear Receptor Subfamily 4, Group A, Member 1/metabolism; Nuclear Receptor Subfamily 4, Group A, Member 2/genetics; Nuclear Receptor Subfamily 4, Group A, Member 2/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Adrenal Cortex Neoplasms / Adrenocortical Adenoma / Aldosterone / Wnt Signaling Pathway / Hyperaldosteronism Type of study: Etiology_studies Limits: Adult / Animals / Female / Humans / Male / Middle aged Language: En Journal: Hum Mol Genet Journal subject: BIOLOGIA MOLECULAR / GENETICA MEDICA Year: 2014 Type: Article Affiliation country: France

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