Syntaxin 13, a genetic modifier of mutant CHMP2B in frontotemporal dementia, is required for autophagosome maturation.

Lu, Yubing; Zhang, Zhijun; Sun, Danqiong; Sweeney, Sean T; Gao, Fen-Biao

Lu, Yubing; Zhang, Zhijun; Sun, Danqiong; Sweeney, Sean T; Gao, Fen-Biao.

Affiliation

Lu Y; Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, 01605 USA.
Zhang Z; Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, 01605 USA.
Sun D; Gladstone Institute of Neurological Disease, San Francisco, CA 94158, USA.
Sweeney ST; Department of Biology, University of York, Heslington, York, YO10 5DD, UK.
Gao FB; Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, 01605 USA.

Mol Cell ; 52(2): 264-71, 2013 Oct 24.

Article in En | MEDLINE | ID: mdl-24095276

Subject(s)

Autophagy; Drosophila Proteins/metabolism; Endosomal Sorting Complexes Required for Transport/metabolism; Phagosomes/metabolism; Qa-SNARE Proteins/metabolism; Vesicular Transport Proteins/metabolism; Animals; Blotting, Western; Drosophila Proteins/genetics; Drosophila melanogaster/genetics; Drosophila melanogaster/metabolism; Endosomal Sorting Complexes Required for Transport/genetics; Eye Abnormalities/genetics; Eye Abnormalities/metabolism; Frontotemporal Dementia/genetics; Frontotemporal Dementia/metabolism; HEK293 Cells; HeLa Cells; Humans; Luminescent Proteins/genetics; Luminescent Proteins/metabolism; Microscopy, Confocal; Microscopy, Immunoelectron; Microtubule-Associated Proteins/genetics; Microtubule-Associated Proteins/metabolism; Mutation; N-Ethylmaleimide-Sensitive Proteins/genetics; N-Ethylmaleimide-Sensitive Proteins/metabolism; Phagosomes/ultrastructure; Phenotype; Qa-SNARE Proteins/genetics; RNA Interference; Vesicular Transport Proteins/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autophagy / Phagosomes / Drosophila Proteins / Vesicular Transport Proteins / Qa-SNARE Proteins / Endosomal Sorting Complexes Required for Transport Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Mol Cell Journal subject: BIOLOGIA MOLECULAR Year: 2013 Type: Article

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