A novel bi-layer ascending release osmotic pump tablet: in vitro investigation and in vivo investigation in pharmacokinetic study and IVIVC evaluation.

Xu, Heming; Li, Zhao; Pan, Hao; Zhang, Zhihong; Liu, Dandan; Tian, Baocheng; Ma, Shilin; Song, Shilong; Pan, Weisan

Xu, Heming; Li, Zhao; Pan, Hao; Zhang, Zhihong; Liu, Dandan; Tian, Baocheng; Ma, Shilin; Song, Shilong; Pan, Weisan.

Affiliation

Xu H; Department of Pharmaceutics, School of Pharmaceutical science, Shenyang Pharmaceutical University, 103 Wenhua Road, 110016 Shenyang, China.

Int J Pharm ; 458(1): 181-7, 2013 Dec 15.

Article in En | MEDLINE | ID: mdl-24095815

Subject(s)

Osmosis/drug effects; Tablets/pharmacokinetics; Animals; Chemistry, Pharmaceutical/methods; Dogs; Drug Delivery Systems/methods; Isoxazoles/chemistry; Isoxazoles/pharmacokinetics; Paliperidone Palmitate; Polymers/chemistry; Polymers/pharmacokinetics; Pyrimidines/chemistry; Pyrimidines/pharmacokinetics; Sodium Chloride/chemistry; Sodium Chloride/pharmacokinetics; Suspensions/administration & dosage; Suspensions/pharmacokinetics; Tablets/chemistry

Key words

Ascending release osmotic pump; Mechanism verification; Paliperidone; Rate balance

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Osmosis / Tablets Limits: Animals Language: En Journal: Int J Pharm Year: 2013 Type: Article Affiliation country: China

Fulltext

XML

PubMed Links

Search on Google