Distinct specificity and single-molecule kinetics characterize the interaction of pathogenic and non-pathogenic antibodies against platelet factor 4-heparin complexes with platelet factor 4.

Litvinov, Rustem I; Yarovoi, Serge V; Rauova, Lubica; Barsegov, Valeri; Sachais, Bruce S; Rux, Ann H; Hinds, Jillian L; Arepally, Gowthami M; Cines, Douglas B; Weisel, John W

Litvinov, Rustem I; Yarovoi, Serge V; Rauova, Lubica; Barsegov, Valeri; Sachais, Bruce S; Rux, Ann H; Hinds, Jillian L; Arepally, Gowthami M; Cines, Douglas B; Weisel, John W.

Affiliation

Litvinov RI; From the Department of Cell and Developmental Biology and.

J Biol Chem ; 288(46): 33060-70, 2013 Nov 15.

Article in En | MEDLINE | ID: mdl-24097975

Subject(s)

Antibodies, Monoclonal/chemistry; Antibody Specificity; Anticoagulants/chemistry; Autoantibodies/chemistry; Heparin/chemistry; Platelet Factor 4/chemistry; Antibodies, Monoclonal/immunology; Anticoagulants/adverse effects; Anticoagulants/immunology; Anticoagulants/therapeutic use; Autoantibodies/immunology; Binding Sites, Antibody; Heparin/adverse effects; Heparin/immunology; Heparin/therapeutic use; Humans; Kinetics; Platelet Factor 4/immunology; Thrombocytopenia/chemically induced; Thrombocytopenia/immunology

Key words

Antibodies; Heparin-binding Protein; Platelets; Single Molecule Biophysics; Thrombosis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Autoantibodies / Platelet Factor 4 / Heparin / Antibodies, Monoclonal / Antibody Specificity / Anticoagulants Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Biol Chem Year: 2013 Type: Article

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