Histone acetyltransferase Hbo1 destabilizes estrogen receptor &#945; by ubiquitination and modulates proliferation of breast cancers.

Iizuka, Masayoshi; Susa, Takao; Takahashi, Yoshihisa; Tamamori-Adachi, Mimi; Kajitani, Takashi; Okinaga, Hiroko; Fukusato, Toshio; Okazaki, Tomoki

Histone acetyltransferase Hbo1 destabilizes estrogen receptor α by ubiquitination and modulates proliferation of breast cancers.

Iizuka, Masayoshi; Susa, Takao; Takahashi, Yoshihisa; Tamamori-Adachi, Mimi; Kajitani, Takashi; Okinaga, Hiroko; Fukusato, Toshio; Okazaki, Tomoki.

Affiliation

Iizuka M; Department of Biochemistry, Teikyo University School of Medicine, Tokyo, Japan.

Cancer Sci ; 104(12): 1647-55, 2013 Dec.

Article in En | MEDLINE | ID: mdl-24125069

Subject(s)

Breast Neoplasms/pathology; Estrogen Receptor alpha/metabolism; Histone Acetyltransferases/metabolism; Ubiquitination; Adult; Aged; Aged, 80 and over; Breast Neoplasms/genetics; Breast Neoplasms/metabolism; Cell Line, Tumor; Cell Proliferation; Estrogen Antagonists/pharmacology; Female; Gene Expression Regulation, Neoplastic; Histone Acetyltransferases/genetics; Humans; MCF-7 Cells; Middle Aged; RNA Interference; RNA, Small Interfering; Tamoxifen/pharmacology; Transcription, Genetic

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Breast Neoplasms / Estrogen Receptor alpha / Histone Acetyltransferases / Ubiquitination Limits: Adult / Aged / Aged80 / Female / Humans / Middle aged Language: En Journal: Cancer Sci Year: 2013 Type: Article Affiliation country: Japan

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