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LRRK2 mutations cause mitochondrial DNA damage in iPSC-derived neural cells from Parkinson's disease patients: reversal by gene correction.
Sanders, Laurie H; Laganière, Josée; Cooper, Oliver; Mak, Sally K; Vu, B Joseph; Huang, Y Anne; Paschon, David E; Vangipuram, Malini; Sundararajan, Ramya; Urnov, Fyodor D; Langston, J William; Gregory, Philip D; Zhang, H Steve; Greenamyre, J Timothy; Isacson, Ole; Schüle, Birgitt.
Affiliation
  • Sanders LH; Pittsburgh Institute for Neurodegenerative Diseases, Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15260, USA.
  • Laganière J; Sangamo BioSciences, Inc., Point Richmond Tech Center, 501 Canal Boulevard, Suite A100, Richmond, CA 94804, USA.
  • Cooper O; Neuroregeneration Institute, McLean Hospital/Harvard Medical School, Belmont, MA 02478, USA.
  • Mak SK; The Parkinson's Institute, 675 Almanor Avenue, Sunnyvale, CA 94025, USA.
  • Vu BJ; Sangamo BioSciences, Inc., Point Richmond Tech Center, 501 Canal Boulevard, Suite A100, Richmond, CA 94804, USA.
  • Huang YA; The Parkinson's Institute, 675 Almanor Avenue, Sunnyvale, CA 94025, USA.
  • Paschon DE; Sangamo BioSciences, Inc., Point Richmond Tech Center, 501 Canal Boulevard, Suite A100, Richmond, CA 94804, USA.
  • Vangipuram M; The Parkinson's Institute, 675 Almanor Avenue, Sunnyvale, CA 94025, USA.
  • Sundararajan R; The Parkinson's Institute, 675 Almanor Avenue, Sunnyvale, CA 94025, USA.
  • Urnov FD; Sangamo BioSciences, Inc., Point Richmond Tech Center, 501 Canal Boulevard, Suite A100, Richmond, CA 94804, USA.
  • Langston JW; The Parkinson's Institute, 675 Almanor Avenue, Sunnyvale, CA 94025, USA.
  • Gregory PD; Sangamo BioSciences, Inc., Point Richmond Tech Center, 501 Canal Boulevard, Suite A100, Richmond, CA 94804, USA.
  • Zhang HS; Sangamo BioSciences, Inc., Point Richmond Tech Center, 501 Canal Boulevard, Suite A100, Richmond, CA 94804, USA.
  • Greenamyre JT; Pittsburgh Institute for Neurodegenerative Diseases, Department of Neurology, University of Pittsburgh, Pittsburgh, PA 15260, USA. Electronic address: jgreena@pitt.edu.
  • Isacson O; Neuroregeneration Institute, McLean Hospital/Harvard Medical School, Belmont, MA 02478, USA. Electronic address: isacson@hms.harvard.edu.
  • Schüle B; The Parkinson's Institute, 675 Almanor Avenue, Sunnyvale, CA 94025, USA. Electronic address: bschuele@thepi.org.
Neurobiol Dis ; 62: 381-6, 2014 Feb.
Article in En | MEDLINE | ID: mdl-24148854
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / DNA Damage / DNA, Mitochondrial / Protein Serine-Threonine Kinases / Targeted Gene Repair / Neural Stem Cells Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Neurobiol Dis Journal subject: NEUROLOGIA Year: 2014 Type: Article Affiliation country: United States
Fulltext
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PubMed Links
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Parkinson Disease / DNA Damage / DNA, Mitochondrial / Protein Serine-Threonine Kinases / Targeted Gene Repair / Neural Stem Cells Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Neurobiol Dis Journal subject: NEUROLOGIA Year: 2014 Type: Article Affiliation country: United States