Human gene variants linked to enhanced NLRP3 activity limit intramacrophage growth of Mycobacterium tuberculosis.

Eklund, Daniel; Welin, Amanda; Andersson, Henrik; Verma, Deepti; Söderkvist, Peter; Stendahl, Olle; Särndahl, Eva; Lerm, Maria

Eklund, Daniel; Welin, Amanda; Andersson, Henrik; Verma, Deepti; Söderkvist, Peter; Stendahl, Olle; Särndahl, Eva; Lerm, Maria.

Affiliation

Eklund D; Division of Microbiology and Molecular Medicine.

J Infect Dis ; 209(5): 749-53, 2014 Mar 01.

Article in En | MEDLINE | ID: mdl-24158955

Subject(s)

Carrier Proteins/genetics; Genetic Variation/genetics; Macrophages/microbiology; Mycobacterium tuberculosis/growth & development; Tuberculosis/genetics; CARD Signaling Adaptor Proteins/genetics; CARD Signaling Adaptor Proteins/metabolism; Carrier Proteins/metabolism; Female; Humans; Inflammasomes/genetics; Inflammasomes/metabolism; Interleukin-1beta/genetics; Interleukin-1beta/metabolism; Macrophages/metabolism; Male; NLR Family, Pyrin Domain-Containing 3 Protein; Neoplasm Proteins/genetics; Neoplasm Proteins/metabolism; Tuberculosis/metabolism; Tuberculosis/microbiology

Key words

C10X; CARD8; IL-1ß; NLRP3; Q705K; human macrophage; inflammasome; mycobacteria; tuberculosis

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Tuberculosis / Genetic Variation / Carrier Proteins / Macrophages / Mycobacterium tuberculosis Limits: Female / Humans / Male Language: En Journal: J Infect Dis Year: 2014 Type: Article

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