Synthesis of novel 7-substituted pyrido[2',3':4,5]furo[3,2-d]pyrimidin-4-amines and their N-aryl analogues and evaluation of their inhibitory activity against Ser/Thr kinases.

Deau, Emmanuel; Loidreau, Yvonnick; Marchand, Pascal; Nourrisson, Marie-Renée; Loaëc, Nadège; Meijer, Laurent; Levacher, Vincent; Besson, Thierry

Deau, Emmanuel; Loidreau, Yvonnick; Marchand, Pascal; Nourrisson, Marie-Renée; Loaëc, Nadège; Meijer, Laurent; Levacher, Vincent; Besson, Thierry.

Affiliation

Deau E; Normandie Univ, COBRA, UMR 6014 & FR 3038; Univ Rouen; INSA Rouen; CNRS, Bâtiment IRCOF, 1 rue Tesnière, 76821 Mont St Aignan Cedex, France.

Bioorg Med Chem Lett ; 23(24): 6784-8, 2013 Dec 15.

Article in En | MEDLINE | ID: mdl-24176400

Subject(s)

Amines/chemistry; Amines/pharmacology; Heterocyclic Compounds, 3-Ring/chemical synthesis; Heterocyclic Compounds, 3-Ring/pharmacology; Protein Kinase Inhibitors/chemical synthesis; Protein Kinase Inhibitors/pharmacology; Protein Serine-Threonine Kinases/antagonists & inhibitors; Amines/chemical synthesis; Amines/metabolism; Catalysis; Cyclization; Enzyme Activation/drug effects; Heterocyclic Compounds, 3-Ring/chemistry; Heterocyclic Compounds, 3-Ring/metabolism; Microwaves; Palladium/chemistry; Protein Binding/drug effects; Protein Kinase Inhibitors/chemistry; Protein Kinase Inhibitors/metabolism; Protein Serine-Threonine Kinases/metabolism; Pyridines/chemistry; Pyrimidines/chemistry; Structure-Activity Relationship

Key words

Dimroth rearrangement; Formamide degradation; Microwave-assisted chemistry; Serine/threonine kinases inhibitors; SuzukiMiyaura cross-coupling

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Protein Serine-Threonine Kinases / Protein Kinase Inhibitors / Amines / Heterocyclic Compounds, 3-Ring Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2013 Type: Article Affiliation country: France

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