Expanded access study of patients with advanced basal cell carcinoma treated with the Hedgehog pathway inhibitor, vismodegib.

Chang, Anne Lynn S; Solomon, James A; Hainsworth, John D; Goldberg, Leonard; McKenna, Edward; Day, Bann-mo; Chen, Diana M; Weiss, Glen J

Chang, Anne Lynn S; Solomon, James A; Hainsworth, John D; Goldberg, Leonard; McKenna, Edward; Day, Bann-mo; Chen, Diana M; Weiss, Glen J.

Affiliation

Chang AL; Stanford University School of Medicine, Stanford, California. Electronic address: alschang@stanford.edu.
Solomon JA; Ameriderm Research, Ormond Beach, Florida; Sarah Cannon Research Institute, Nashville, Tennessee; University of Illinois, Urbana Champaign, College of Medicine, Urbana, Illinois.
Hainsworth JD; University of Central Florida, College of Medicine, Orlando, Florida.
Goldberg L; Dermsurgery Associates, Houston, Texas.
McKenna E; Genentech Inc, South San Francisco, California.
Day BM; Genentech Inc, South San Francisco, California.
Chen DM; Genentech Inc, South San Francisco, California.
Weiss GJ; Virginia G. Piper Cancer Center Clinical Trials at Scottsdale Healthcare, Scottsdale, Arizona.

J Am Acad Dermatol ; 70(1): 60-9, 2014 Jan.

Article in En | MEDLINE | ID: mdl-24189279

Subject(s)

Anilides/therapeutic use; Antineoplastic Agents/therapeutic use; Bone Neoplasms/secondary; Carcinoma, Basal Cell/drug therapy; Pyridines/therapeutic use; Skin Neoplasms/drug therapy; Adult; Aged; Aged, 80 and over; Alopecia/chemically induced; Anilides/adverse effects; Antineoplastic Agents/adverse effects; Carcinoma, Basal Cell/secondary; Diarrhea/chemically induced; Disease Progression; Dysgeusia/chemically induced; Female; Humans; Male; Middle Aged; Pyridines/adverse effects; Skin Neoplasms/pathology; Spasm/chemically induced; Treatment Outcome; Young Adult

Key words

AE; BCC; BCNS; ECOG; Eastern Cooperative Oncology Group; FDA; Hedgehog pathway inhibitor; ORR; RECIST; Response Evaluation Criteria in Solid Tumors; SMO; Smoothened; TEAE; US Food and Drug Administration; adverse event; basal cell carcinoma; basal cell nevus syndrome; expanded access; locally advanced; metastatic; objective response rate; treatment-emergent adverse event; vismodegib

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Skin Neoplasms / Bone Neoplasms / Carcinoma, Basal Cell / Anilides / Antineoplastic Agents Type of study: Clinical_trials / Prognostic_studies Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: J Am Acad Dermatol Year: 2014 Type: Article

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