Disturbed follicular architecture in B cell A disintegrin and metalloproteinase (ADAM)10 knockouts is mediated by compensatory increases in ADAM17 and TNF-&#945; shedding.

Folgosa, Lauren; Zellner, Hannah B; El Shikh, Mohey Eldin; Conrad, Daniel H

Disturbed follicular architecture in B cell A disintegrin and metalloproteinase (ADAM)10 knockouts is mediated by compensatory increases in ADAM17 and TNF-α shedding.

Folgosa, Lauren; Zellner, Hannah B; El Shikh, Mohey Eldin; Conrad, Daniel H.

Affiliation

Folgosa L; Center for Clinical and Translational Research, Virginia Commonwealth University, Richmond, VA 23298;

J Immunol ; 191(12): 5951-8, 2013 Dec 15.

Article in En | MEDLINE | ID: mdl-24227779

Subject(s)

ADAM Proteins/physiology; Amyloid Precursor Protein Secretases/physiology; B-Lymphocytes/metabolism; Gene Expression Regulation/immunology; Germinal Center/ultrastructure; Lymph Nodes/ultrastructure; Membrane Proteins/physiology; Tumor Necrosis Factor-alpha/physiology; ADAM Proteins/biosynthesis; ADAM Proteins/deficiency; ADAM Proteins/genetics; ADAM10 Protein; ADAM17 Protein; Amyloid Precursor Protein Secretases/deficiency; Animals; Cells, Cultured; Dendritic Cells, Follicular/pathology; Female; Germinal Center/metabolism; Lymph Nodes/metabolism; Male; Membrane Proteins/deficiency; Mice; Mice, Congenic; Mice, Inbred C57BL; Mice, Knockout; RNA Stability/physiology; RNA, Messenger/metabolism; Radiation Chimera; Signal Transduction; Tumor Necrosis Factor-alpha/biosynthesis; Tumor Necrosis Factor-alpha/blood; Tumor Necrosis Factor-alpha/genetics; Up-Regulation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: B-Lymphocytes / Gene Expression Regulation / Tumor Necrosis Factor-alpha / Germinal Center / ADAM Proteins / Amyloid Precursor Protein Secretases / Lymph Nodes / Membrane Proteins Limits: Animals Language: En Journal: J Immunol Year: 2013 Type: Article

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