Discovery of an irreversible HCV NS5B polymerase inhibitor.

Zeng, Qingbei; Nair, Anilkumar G; Rosenblum, Stuart B; Huang, Hsueh-Cheng; Lesburg, Charles A; Jiang, Yueheng; Selyutin, Oleg; Chan, Tin-Yau; Bennett, Frank; Chen, Kevin X; Venkatraman, Srikanth; Sannigrahi, Mousumi; Velazquez, Francisco; Duca, Jose S; Gavalas, Stephen; Huang, Yuhua; Pu, Haiyan; Wang, Li; Pinto, Patrick; Vibulbhan, Bancha; Agrawal, Sony; Ferrari, Eric; Jiang, Chuan-kui; Li, Cheng; Hesk, David; Gesell, Jennifer; Sorota, Steve; Shih, Neng-Yang; Njoroge, F George; Kozlowski, Joseph A

Zeng, Qingbei; Nair, Anilkumar G; Rosenblum, Stuart B; Huang, Hsueh-Cheng; Lesburg, Charles A; Jiang, Yueheng; Selyutin, Oleg; Chan, Tin-Yau; Bennett, Frank; Chen, Kevin X; Venkatraman, Srikanth; Sannigrahi, Mousumi; Velazquez, Francisco; Duca, Jose S; Gavalas, Stephen; Huang, Yuhua; Pu, Haiyan; Wang, Li; Pinto, Patrick; Vibulbhan, Bancha; Agrawal, Sony; Ferrari, Eric; Jiang, Chuan-kui; Li, Cheng; Hesk, David; Gesell, Jennifer; Sorota, Steve; Shih, Neng-Yang; Njoroge, F George; Kozlowski, Joseph A.

Affiliation

Zeng Q; Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA.

Bioorg Med Chem Lett ; 23(24): 6585-7, 2013 Dec 15.

Article in En | MEDLINE | ID: mdl-24252545

Subject(s)

Enzyme Inhibitors/chemistry; Hepacivirus/enzymology; Indoles/chemistry; Quinolines/chemistry; Viral Nonstructural Proteins/antagonists & inhibitors; Animals; Crystallography, X-Ray; Dogs; Drug Evaluation, Preclinical; Enzyme Activation/drug effects; Enzyme Inhibitors/chemical synthesis; Enzyme Inhibitors/pharmacokinetics; Enzyme Inhibitors/pharmacology; Haplorhini; Humans; Indoles/chemical synthesis; Indoles/pharmacokinetics; Indoles/pharmacology; Male; Molecular Dynamics Simulation; Protein Binding; Protein Structure, Tertiary; Quinolines/chemical synthesis; Quinolines/pharmacokinetics; Quinolines/pharmacology; Rats; Rats, Sprague-Dawley; Viral Nonstructural Proteins/metabolism

Key words

HCV; NS5B polymerase

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Quinolines / Viral Nonstructural Proteins / Hepacivirus / Enzyme Inhibitors / Indoles Limits: Animals / Humans / Male Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2013 Type: Article Affiliation country: United States

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