Inhibition of IRAK-4 activity for rescuing endotoxin LPS-induced septic mortality in mice by lonicerae flos extract.

Park, Sun Hong; Roh, Eunmiri; Kim, Hyun Soo; Baek, Seung-Il; Choi, Nam Song; Kim, Narae; Hwang, Bang Yeon; Han, Sang-Bae; Kim, Youngsoo

Park, Sun Hong; Roh, Eunmiri; Kim, Hyun Soo; Baek, Seung-Il; Choi, Nam Song; Kim, Narae; Hwang, Bang Yeon; Han, Sang-Bae; Kim, Youngsoo.

Affiliation

Park SH; College of Pharmacy, Chungbuk National University, Cheongju 361-763, Republic of Korea.

Biochem Biophys Res Commun ; 442(3-4): 183-8, 2013 Dec 13.

Article in En | MEDLINE | ID: mdl-24269819

Subject(s)

Anti-Inflammatory Agents, Non-Steroidal/therapeutic use; Chlorogenic Acid/therapeutic use; Interleukin-1 Receptor-Associated Kinases/antagonists & inhibitors; Lonicera/chemistry; Plant Extracts/therapeutic use; Sepsis/drug therapy; Animals; Chlorogenic Acid/analysis; Chlorogenic Acid/chemistry; Endotoxins; Lipopolysaccharides; Metabolic Networks and Pathways/drug effects; Mice; Mice, Inbred C57BL; NF-kappa B/metabolism; Plant Extracts/chemistry; Sepsis/mortality; Transcription Factor AP-1/metabolism

Key words

AP-1; Anti-inflammatory therapy; CGA; Chlorogenic acid isomers; Endotoxin LPS; HS-23; IL-1 receptor-associated kinase 4; IRAK-4; Lonicerae flos extract; MyD88; NF-κB; Septic mortality; TBK-1; TLR; TNF receptor-associated factor (TRAF) family member-associated NF-κB activator (TANK)-binding kinase 1; TRIF; activating protein 1; chlorogenic acid; lonicerae flos extract; myeloid differentiation factor 88; nuclear factor-κB; toll-like receptor; toll/IL-1 receptor (TIR)-containing adaptor inducing IFN-ß

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plant Extracts / Chlorogenic Acid / Anti-Inflammatory Agents, Non-Steroidal / Sepsis / Lonicera / Interleukin-1 Receptor-Associated Kinases Limits: Animals Language: En Journal: Biochem Biophys Res Commun Year: 2013 Type: Article

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