Macrophage mitochondrial damage from StAR transport of 7-hydroperoxycholesterol: implications for oxidative stress-impaired reverse cholesterol transport.

Korytowski, Witold; Wawak, Katarzyna; Pabisz, Pawel; Schmitt, Jared C; Girotti, Albert W

Korytowski, Witold; Wawak, Katarzyna; Pabisz, Pawel; Schmitt, Jared C; Girotti, Albert W.

Affiliation

Korytowski W; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, USA; Department of Biophysics, Jagiellonian University, Krakow, Poland. Electronic address: witekkor@mcw.edu.
Wawak K; Department of Biophysics, Jagiellonian University, Krakow, Poland.
Pabisz P; Department of Biophysics, Jagiellonian University, Krakow, Poland.
Schmitt JC; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, USA.
Girotti AW; Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, USA.

FEBS Lett ; 588(1): 65-70, 2014 Jan 03.

Article in En | MEDLINE | ID: mdl-24269887

Subject(s)

Cholesterol/analogs & derivatives; Macrophages/metabolism; Mitochondria/metabolism; Phosphoproteins/metabolism; ATP Binding Cassette Transporter 1/metabolism; Animals; Biological Transport/drug effects; Blotting, Western; Bucladesine/pharmacology; Cell Line; Cell Membrane/drug effects; Cell Membrane/metabolism; Cell Survival/drug effects; Cholesterol/metabolism; Cholesterol/pharmacology; Dose-Response Relationship, Drug; Lipid Peroxidation/drug effects; Macrophages/cytology; Macrophages/drug effects; Membrane Potential, Mitochondrial/drug effects; Mice; Oxidative Stress; Phosphoproteins/genetics; RNA Interference; Time Factors

Key words

1-palmitoyl-2-sn-glycero-3-phosphocholine; 3-(4,5-dimethylthiazolyl-2-yl)-2,5-diphenyltetrazolium bromide; 3ß-hydroxycholest-5-ene-7α-hydroperoxide; 4,4-difluoro-5-(4-phenyl-1,3-butadienyl)-4-bora-3a,4a-diaza-s-inda-cene-3-undecanoic acid; 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethyl-benzimidazolylcarbocyanine iodide; 7α-OH; 7α-OOH; ABCA1; ATP binding cassette transporter A1; C11-BODIPY; ChOOH(s); Cholesterol hydroperoxide; JC-1; MTT; Macrophage; Oxidative stress; PBS; POPC; Reverse cholesterol transport; SUV(s); StAR protein; StarD1; StarD4; cholest-5-ene-3ß,7α-diol; cholesterol hydroperoxide(s); db-cAMP; dibutyryl-cAMP; phosphate-buffered saline; small unilamellar vesicle(s); type-1 steroidogenic acute regulatory domain protein; type-4 steroidogenic acute regulatory domain protein

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphoproteins / Cholesterol / Macrophages / Mitochondria Limits: Animals Language: En Journal: FEBS Lett Year: 2014 Type: Article

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