Identification of collagenase as a critical virulence factor for invasiveness and transmission of pathogenic Leptospira species.

Kassegne, Kokouvi; Hu, Weilin; Ojcius, David M; Sun, Dexter; Ge, Yumei; Zhao, Jinfang; Yang, X Frank; Li, Lanjuan; Yan, Jie

Kassegne, Kokouvi; Hu, Weilin; Ojcius, David M; Sun, Dexter; Ge, Yumei; Zhao, Jinfang; Yang, X Frank; Li, Lanjuan; Yan, Jie.

Affiliation

Kassegne K; Division of Basic Medical Microbiology, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, First Affiliated Hospital, Zhejiang University School of Medicine.

J Infect Dis ; 209(7): 1105-15, 2014 Apr 01.

Article in En | MEDLINE | ID: mdl-24277745

Subject(s)

Collagenases/metabolism; Leptospira interrogans/enzymology; Leptospira interrogans/pathogenicity; Virulence Factors/metabolism; Animals; Blotting, Western; Cell Line; Collagen/metabolism; Collagenases/genetics; Cricetinae; Disease Models, Animal; Endothelial Cells/microbiology; Fibroblasts/microbiology; Gene Deletion; Gene Expression Profiling; Genetic Complementation Test; Humans; Hydrolysis; Leptospirosis/microbiology; Leptospirosis/pathology; Male; Mesocricetus; Real-Time Polymerase Chain Reaction; Transcytosis; Virulence; Virulence Factors/genetics

Key words

Collagenase; Invasiveness; Leptospira; Tissue injury; Transmission

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Collagenases / Virulence Factors / Leptospira interrogans Type of study: Diagnostic_studies / Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: J Infect Dis Year: 2014 Type: Article

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