Memory and synaptic deficits in Hip14/DHHC17 knockout mice.
Proc Natl Acad Sci U S A
; 110(50): 20296-301, 2013 Dec 10.
Article
in En
| MEDLINE
| ID: mdl-24277827
ABSTRACT
Palmitoylation of neurotransmitter receptors and associated scaffold proteins regulates their membrane association in a rapid, reversible, and activity-dependent fashion. This makes palmitoylation an attractive candidate as a key regulator of the fast, reversible, and activity-dependent insertion of synaptic proteins required during the induction and expression of long-term plasticity. Here we describe that the constitutive loss of huntingtin interacting protein 14 (Hip14, also known as DHHC17), a single member of the broad palmitoyl acyltransferase (PAT) family, produces marked alterations in synaptic function in varied brain regions and significantly impairs hippocampal memory and synaptic plasticity. The data presented suggest that, even though the substrate pool is overlapping for the 23 known PAT family members, the function of a single PAT has marked effects upon physiology and cognition. Moreover, an improved understanding of the role of PATs in synaptic modification and maintenance highlights a potential strategy for intervention against early cognitive impairments in neurodegenerative disease.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Synapses
/
Acyltransferases
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Long-Term Potentiation
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Memory Disorders
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Neuronal Plasticity
Limits:
Animals
Language:
En
Journal:
Proc Natl Acad Sci U S A
Year:
2013
Type:
Article