Your browser doesn't support javascript.
loading
Phenotypic impact of deregulated expression of class I histone deacetylases in urothelial cell carcinoma of the bladder.
Junqueira-Neto, Susana; Vieira, Filipa Q; Montezuma, Diana; Costa, Natália R; Antunes, Luís; Baptista, Tiago; Oliveira, Ana Isabel; Graça, Inês; Rodrigues, Ângelo; Magalhães, José S; Oliveira, Jorge; Henrique, Rui; Jerónimo, Carmen.
Affiliation
  • Junqueira-Neto S; Cancer Epigenetics Group, Research Center of the Portuguese Oncology Institute-Porto, Porto, Portugal.
  • Vieira FQ; Cancer Epigenetics Group, Research Center of the Portuguese Oncology Institute-Porto, Porto, Portugal.
  • Montezuma D; School of Allied Health Sciences ESTSP, Polytechnic of Porto, Porto, Portugal.
  • Costa NR; Cancer Epigenetics Group, Research Center of the Portuguese Oncology Institute-Porto, Porto, Portugal.
  • Antunes L; Department of Pathology, Portuguese Oncology Institute, Porto, Portugal.
  • Baptista T; Cancer Epigenetics Group, Research Center of the Portuguese Oncology Institute-Porto, Porto, Portugal.
  • Oliveira AI; Department of Epidemiology, Portuguese Oncology Institute, Porto, Portugal.
  • Graça I; Cancer Epigenetics Group, Research Center of the Portuguese Oncology Institute-Porto, Porto, Portugal.
  • Rodrigues Â; Cancer Epigenetics Group, Research Center of the Portuguese Oncology Institute-Porto, Porto, Portugal.
  • Magalhães JS; Cancer Epigenetics Group, Research Center of the Portuguese Oncology Institute-Porto, Porto, Portugal.
  • Oliveira J; School of Allied Health Sciences ESTSP, Polytechnic of Porto, Porto, Portugal.
  • Henrique R; Department of Pathology, Portuguese Oncology Institute, Porto, Portugal.
  • Jerónimo C; Department of Urology, Portuguese Oncology Institute, Porto, Portugal.
Mol Carcinog ; 54(7): 523-31, 2015 Jul.
Article in En | MEDLINE | ID: mdl-24293253
ABSTRACT
Deregulated expression of histone deacetylases (HDACs) has been implicated in tumorigenesis. Herein, we investigated class I HDACs expression in bladder urothelial cell carcinoma (BUCC), its prognostic value and biological significance. Significantly increased transcript levels of all HDACs were found in BUCC compared to 20 normal mucosas, and these were higher in lower grade and stage tumors. Increased HDAC3 levels were associated with improved patient survival. SiRNA experiments showed decrease cell viability and motility, and increased apoptosis. We concluded that class I HDACs play an important role in bladder carcinogenesis through deregulation of proliferation, migration and apoptosis, constituting putative therapeutic targets.
Subject(s)
Key words
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Urinary Bladder / Urinary Bladder Neoplasms / Gene Expression Regulation, Neoplastic / Histone Deacetylases Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Mol Carcinog Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2015 Type: Article Affiliation country: Portugal
Fulltext
Print
XML
PubMed Links
Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Urinary Bladder / Urinary Bladder Neoplasms / Gene Expression Regulation, Neoplastic / Histone Deacetylases Limits: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Mol Carcinog Journal subject: BIOLOGIA MOLECULAR / NEOPLASIAS Year: 2015 Type: Article Affiliation country: Portugal