Modulation of Ras signaling alters the toxicity of hydroquinone, a benzene metabolite and component of cigarette smoke.

North, Matthew; Shuga, Joe; Fromowitz, Michele; Loguinov, Alexandre; Shannon, Kevin; Zhang, Luoping; Smith, Martyn T; Vulpe, Chris D

North, Matthew; Shuga, Joe; Fromowitz, Michele; Loguinov, Alexandre; Shannon, Kevin; Zhang, Luoping; Smith, Martyn T; Vulpe, Chris D.

Affiliation

Vulpe CD; Department of Nutritional Science and Toxicology, University of California, Berkeley, California 94720, USA. vulpe@berkeley.edu.

BMC Cancer ; 14: 6, 2014 Jan 05.

Article in En | MEDLINE | ID: mdl-24386979

Subject(s)

Hematopoietic Stem Cells/drug effects; Hydroquinones/toxicity; Saccharomyces cerevisiae/drug effects; Signal Transduction/drug effects; Smoke/adverse effects; Smoking/adverse effects; ras Proteins/metabolism; Animals; Cell Proliferation/drug effects; Cells, Cultured; Dose-Response Relationship, Drug; Erythrocytes/drug effects; Erythrocytes/metabolism; Erythrocytes/pathology; GTPase-Activating Proteins/genetics; GTPase-Activating Proteins/metabolism; Genes, Neurofibromatosis 1; Hematopoietic Stem Cells/metabolism; Hematopoietic Stem Cells/pathology; Mice; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Knockout; Micronuclei, Chromosome-Defective/chemically induced; Saccharomyces cerevisiae/enzymology; Saccharomyces cerevisiae/genetics; Saccharomyces cerevisiae/growth & development; Saccharomyces cerevisiae Proteins/genetics; Saccharomyces cerevisiae Proteins/metabolism; ras Proteins/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Saccharomyces cerevisiae / Smoke / Hematopoietic Stem Cells / Signal Transduction / Smoking / Ras Proteins / Hydroquinones Limits: Animals Language: En Journal: BMC Cancer Journal subject: NEOPLASIAS Year: 2014 Type: Article

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