The major facilitative folate transporters solute carrier 19A1 and solute carrier 46A1: biology and role in antifolate chemotherapy of cancer.

Matherly, Larry H; Wilson, Mike R; Hou, Zhanjun

Matherly, Larry H; Wilson, Mike R; Hou, Zhanjun.

Affiliation

Matherly LH; Department of Oncology (L.H.M., M.R.W., Z.H.) and Department of Pharmacology (L.H.M.), Wayne State University School of Medicine, Detroit, Michigan; and Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan (L.H.M., Z.H.).

Drug Metab Dispos ; 42(4): 632-49, 2014 Apr.

Article in En | MEDLINE | ID: mdl-24396145

Subject(s)

Folic Acid Antagonists/pharmacokinetics; Folic Acid/metabolism; Neoplasms/drug therapy; Proton-Coupled Folate Transporter/metabolism; Reduced Folate Carrier Protein/metabolism; Aminopterin/administration & dosage; Aminopterin/analogs & derivatives; Aminopterin/pharmacokinetics; Aminopterin/therapeutic use; Animals; Drug Resistance, Neoplasm; Folic Acid Antagonists/administration & dosage; Folic Acid Antagonists/therapeutic use; Humans; Methotrexate/administration & dosage; Methotrexate/pharmacokinetics; Methotrexate/therapeutic use; Neoplasms/metabolism; Proton-Coupled Folate Transporter/genetics; Reduced Folate Carrier Protein/genetics

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Proton-Coupled Folate Transporter / Reduced Folate Carrier Protein / Folic Acid / Folic Acid Antagonists / Neoplasms Limits: Animals / Humans Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2014 Type: Article

Fulltext

XML

PubMed Links

Search on Google