Characterization of hERG1 channel role in mouse colorectal carcinogenesis.

Fiore, Antonella; Carraresi, Laura; Morabito, Angela; Polvani, Simone; Fortunato, Angelo; Lastraioli, Elena; Femia, Angelo P; De Lorenzo, Emanuele; Caderni, Giovanna; Arcangeli, Annarosa

Fiore, Antonella; Carraresi, Laura; Morabito, Angela; Polvani, Simone; Fortunato, Angelo; Lastraioli, Elena; Femia, Angelo P; De Lorenzo, Emanuele; Caderni, Giovanna; Arcangeli, Annarosa.

Affiliation

Fiore A; Department of Experimental and Clinical Medicine, Section of Internal Medicine and Oncology, University of Florence, Florence, Italy; Istituto Toscano Tumori, Florence, Italy.

Cancer Med ; 2(5): 583-94, 2013 Oct.

Article in En | MEDLINE | ID: mdl-24403225

Subject(s)

Carcinogenesis/metabolism; Colorectal Neoplasms/metabolism; Ether-A-Go-Go Potassium Channels/physiology; Adenomatous Polyposis Coli/blood supply; Adenomatous Polyposis Coli/metabolism; Animals; Azoxymethane; Carcinogens; Colorectal Neoplasms/blood supply; Colorectal Neoplasms/chemically induced; Disease Models, Animal; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels/antagonists & inhibitors; Ether-A-Go-Go Potassium Channels/biosynthesis; Ether-A-Go-Go Potassium Channels/genetics; Gene Expression Regulation, Neoplastic; Humans; Intestinal Mucosa/metabolism; Intestine, Large/metabolism; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neoplasm Proteins/biosynthesis; Neoplasm Proteins/genetics; Neovascularization, Pathologic/metabolism; Neovascularization, Pathologic/pathology; Piperidines/pharmacology; Proto-Oncogene Proteins c-akt/biosynthesis; Pyridines/pharmacology; Vascular Endothelial Growth Factor A/biosynthesis

Key words

Apcmin/+ mice; VEGF-A; azoxymethane; colorectal cancer; hERG1 channel

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colorectal Neoplasms / Ether-A-Go-Go Potassium Channels / Carcinogenesis Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Cancer Med Year: 2013 Type: Article Affiliation country: Italy

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