Differential roles of Sirt1 in HIF-1&#945; and HIF-2&#945; mediated hypoxic responses.

Yoon, Haejin; Shin, Seung-Hyun; Shin, Dong Hoon; Chun, Yang-Sook; Park, Jong-Wan

Differential roles of Sirt1 in HIF-1α and HIF-2α mediated hypoxic responses.

Yoon, Haejin; Shin, Seung-Hyun; Shin, Dong Hoon; Chun, Yang-Sook; Park, Jong-Wan.

Affiliation

Yoon H; Departments of Biomedical Sciences and Pharmacology, Ischemic/Hypoxic Disease Institute, Cancer Research Institute, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 110-799, Republic of Korea.
Shin SH; Departments of Biomedical Sciences and Pharmacology, Ischemic/Hypoxic Disease Institute, Cancer Research Institute, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 110-799, Republic of Korea.
Shin DH; Departments of Biomedical Sciences and Pharmacology, Ischemic/Hypoxic Disease Institute, Cancer Research Institute, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 110-799, Republic of Korea.
Chun YS; Departments of Biomedical Sciences and Pharmacology, Ischemic/Hypoxic Disease Institute, Cancer Research Institute, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 110-799, Republic of Korea.
Park JW; Departments of Biomedical Sciences and Pharmacology, Ischemic/Hypoxic Disease Institute, Cancer Research Institute, Seoul National University College of Medicine, 103 Daehak-ro, Jongno-gu, Seoul 110-799, Republic of Korea. Electronic address: parkjw@snu.ac.kr.

Biochem Biophys Res Commun ; 444(1): 36-43, 2014 Jan 31.

Article in En | MEDLINE | ID: mdl-24423936

Subject(s)

Basic Helix-Loop-Helix Transcription Factors/metabolism; Cell Hypoxia/physiology; Hypoxia-Inducible Factor 1, alpha Subunit/metabolism; Sirtuin 1/metabolism; Acetylation; Amino Acid Sequence; Base Sequence; Basic Helix-Loop-Helix Transcription Factors/chemistry; Basic Helix-Loop-Helix Transcription Factors/genetics; Binding Sites; Cell Hypoxia/genetics; Cell Line, Tumor; Cell Proliferation; Gene Knockdown Techniques; HCT116 Cells; HEK293 Cells; HeLa Cells; Hep G2 Cells; Humans; Hypoxia/genetics; Hypoxia/metabolism; Hypoxia-Inducible Factor 1, alpha Subunit/chemistry; Hypoxia-Inducible Factor 1, alpha Subunit/genetics; Lysine/chemistry; Molecular Sequence Data; Neoplasms/metabolism; RNA, Small Interfering/genetics; Sirtuin 1/antagonists & inhibitors; Sirtuin 1/genetics

Key words

Hypoxia; Hypoxia-inducible factors; Lysine acetylation; Sirtuin 1; Transcriptional activity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cell Hypoxia / Basic Helix-Loop-Helix Transcription Factors / Hypoxia-Inducible Factor 1, alpha Subunit / Sirtuin 1 Limits: Humans Language: En Journal: Biochem Biophys Res Commun Year: 2014 Type: Article

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