Akt is essential to induce NADPH-dependent NETosis and to switch the neutrophil death to apoptosis.

Douda, David N; Yip, Lily; Khan, Meraj A; Grasemann, Hartmut; Palaniyar, Nades

Douda, David N; Yip, Lily; Khan, Meraj A; Grasemann, Hartmut; Palaniyar, Nades.

Affiliation

Douda DN; Lung Innate Immunity Research Laboratory, Program in Physiology and Experimental Medicine, SickKids Research Institute, The Hospital for Sick Children, Toronto, ON, Canada.

Blood ; 123(4): 597-600, 2014 Jan 23.

Article in En | MEDLINE | ID: mdl-24458280

Subject(s)

Apoptosis; Gene Expression Regulation, Enzymologic; NADP/chemistry; Neutrophils/pathology; Proto-Oncogene Proteins c-akt/metabolism; Cell Nucleus/metabolism; Humans; Immunoblotting; Inflammation; Microscopy, Fluorescence; Neutrophils/metabolism; Reactive Oxygen Species

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Gene Expression Regulation, Enzymologic / Apoptosis / Proto-Oncogene Proteins c-akt / NADP / Neutrophils Limits: Humans Language: En Journal: Blood Year: 2014 Type: Article Affiliation country: Canada

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