Targeted gene mutation of E2F1 evokes age-dependent synaptic disruption and behavioral deficits.

Ting, Jenhao H; Marks, David R; Schleidt, Stephanie S; Wu, Joanna N; Zyskind, Jacob W; Lindl, Kathryn A; Blendy, Julie A; Pierce, R Christopher; Jordan-Sciutto, Kelly L

Ting, Jenhao H; Marks, David R; Schleidt, Stephanie S; Wu, Joanna N; Zyskind, Jacob W; Lindl, Kathryn A; Blendy, Julie A; Pierce, R Christopher; Jordan-Sciutto, Kelly L.

Affiliation

Ting JH; Department of Pathology, University of Pennsylvania, School of Dental Medicine, Philadelphia, Pennsylvania, USA.

J Neurochem ; 129(5): 850-63, 2014 Jun.

Article in En | MEDLINE | ID: mdl-24460902

Subject(s)

Aging/genetics; Aging/psychology; Behavior, Animal/physiology; E2F1 Transcription Factor/genetics; Mutation/genetics; Synapses/pathology; Animals; Blotting, Western; Cells, Cultured; Gene Targeting; Image Processing, Computer-Assisted; Immunohistochemistry; Memory/physiology; Mice, Inbred C57BL; Motor Activity/physiology; Odorants; Olfaction Disorders/genetics; Olfaction Disorders/psychology; Postural Balance/genetics; Postural Balance/physiology; Psychomotor Performance/physiology; Rats; Rats, Sprague-Dawley; Recognition, Psychology; Smell/genetics; Smell/physiology; Synaptosomes/physiology

Key words

E2F; adult neurogenesis; cell cycle; synaptic proteins; transgenic mice

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Synapses / Behavior, Animal / Aging / E2F1 Transcription Factor / Mutation Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Neurochem Year: 2014 Type: Article Affiliation country: United States

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