Characterization of the biochemical effects of naphthalene on the mouse respiratory system using NMR-based metabolomics.

Hong, Jia-Huei; Lee, Wen-Ching; Hsu, Yu-Ming; Liang, Hao-Jan; Wan, Cho-Hua; Chien, Chung-Liang; Lin, Ching-Yu

Hong, Jia-Huei; Lee, Wen-Ching; Hsu, Yu-Ming; Liang, Hao-Jan; Wan, Cho-Hua; Chien, Chung-Liang; Lin, Ching-Yu.

Affiliation

Hong JH; Institute of Environmental Health, College of Public Health, National Taiwan University, Taipei, 10055, Taiwan, Republic of China.

J Appl Toxicol ; 34(12): 1379-88, 2014 Dec.

Article in En | MEDLINE | ID: mdl-24478122

Subject(s)

Environmental Pollutants/toxicity; Lung/drug effects; Metabolome/drug effects; Naphthalenes/toxicity; Nuclear Magnetic Resonance, Biomolecular; Animals; Bronchoalveolar Lavage Fluid/chemistry; Bronchoalveolar Lavage Fluid/cytology; Dose-Response Relationship, Drug; Epithelial Cells/drug effects; Epithelial Cells/pathology; Injections, Intraperitoneal; Lung/metabolism; Lung/pathology; Male; Mice, Inbred ICR; Principal Component Analysis

Key words

bronchoalveolar lavage fluid; metabolomics; naphthalene; nuclear magnetic resonance; respiratory toxicity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Nuclear Magnetic Resonance, Biomolecular / Environmental Pollutants / Metabolome / Lung / Naphthalenes Limits: Animals Language: En Journal: J Appl Toxicol Year: 2014 Type: Article Affiliation country: China

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