The complex and specific pMHC interactions with diverse HIV-1 TCR clonotypes reveal a structural basis for alterations in CTL function.

Xia, Zhen; Chen, Huabiao; Kang, Seung-gu; Huynh, Tien; Fang, Justin W; Lamothe, Pedro A; Walker, Bruce D; Zhou, Ruhong

Xia, Zhen; Chen, Huabiao; Kang, Seung-gu; Huynh, Tien; Fang, Justin W; Lamothe, Pedro A; Walker, Bruce D; Zhou, Ruhong.

Affiliation

Xia Z; 1] Computational Biology Center, IBM Thomas J. Watson Research Center, Yorktown Heights, New York, USA [2].
Chen H; 1] Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, Massachusetts, USA [2].
Kang SG; Computational Biology Center, IBM Thomas J. Watson Research Center, Yorktown Heights, New York, USA.
Huynh T; Computational Biology Center, IBM Thomas J. Watson Research Center, Yorktown Heights, New York, USA.
Fang JW; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, Massachusetts, USA.
Lamothe PA; Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, Massachusetts, USA.
Walker BD; 1] Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, Massachusetts, USA [2] Howard Hughes Medical Institute, Chevy Chase, Maryland, USA.
Zhou R; 1] Computational Biology Center, IBM Thomas J. Watson Research Center, Yorktown Heights, New York, USA [2] Department of Chemistry, Columbia University, New York, New York, USA.

Sci Rep ; 4: 4087, 2014 Feb 13.

Article in En | MEDLINE | ID: mdl-24522437

Subject(s)

Epitopes/metabolism; HIV-1/metabolism; Histocompatibility Antigens Class I/metabolism; Peptides/metabolism; Receptors, Antigen, T-Cell/metabolism; Binding Sites; Crystallography, X-Ray; Epitopes/genetics; Epitopes/immunology; HLA-B27 Antigen/chemistry; HLA-B27 Antigen/genetics; HLA-B27 Antigen/metabolism; Histocompatibility Antigens Class I/chemistry; Histocompatibility Antigens Class I/genetics; Hydrogen Bonding; Models, Molecular; Molecular Dynamics Simulation; Mutagenesis; Peptides/genetics; Peptides/immunology; Protein Binding; Protein Structure, Quaternary; Receptors, Antigen, T-Cell/chemistry; Thermodynamics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Peptides / Receptors, Antigen, T-Cell / Histocompatibility Antigens Class I / HIV-1 / Epitopes Type of study: Prognostic_studies Language: En Journal: Sci Rep Year: 2014 Type: Article

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