Pulmonary and systemic pharmacokinetics of inhaled and intravenous colistin methanesulfonate in cystic fibrosis patients: targeting advantage of inhalational administration.

Yapa, Shalini; Li, Jian; Patel, Kashyap; Wilson, John W; Dooley, Michael J; George, Johnson; Clark, Denise; Poole, Susan; Williams, Elyssa; Porter, Christopher J H; Nation, Roger L; McIntosh, Michelle P

Yapa, Shalini; Li, Jian; Patel, Kashyap; Wilson, John W; Dooley, Michael J; George, Johnson; Clark, Denise; Poole, Susan; Williams, Elyssa; Porter, Christopher J H; Nation, Roger L; McIntosh, Michelle P.

Affiliation

Yapa SWS; Drug Delivery, Disposition, and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Australia.

Antimicrob Agents Chemother ; 58(5): 2570-9, 2014 05.

Article in En | MEDLINE | ID: mdl-24550334

Subject(s)

Anti-Bacterial Agents/administration & dosage; Anti-Bacterial Agents/pharmacokinetics; Colistin/administration & dosage; Colistin/pharmacokinetics; Cystic Fibrosis/metabolism; Lung/metabolism; Administration, Inhalation; Aged; Aged, 80 and over; Colistin/analogs & derivatives; Colistin/metabolism; Female; Humans; Male; Middle Aged; Sputum/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Colistin / Cystic Fibrosis / Lung / Anti-Bacterial Agents Limits: Aged / Aged80 / Female / Humans / Male / Middle aged Language: En Journal: Antimicrob Agents Chemother Year: 2014 Type: Article Affiliation country: Australia

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