PrP expression level and sensitivity to prion infection.
J Virol
; 88(10): 5870-2, 2014 May.
Article
in En
| MEDLINE
| ID: mdl-24574409
ABSTRACT
Mice overexpressing the prion protein (PrP) sequence from various host species are widely used for measuring infectious titers in prion disease. However, the impact that the transgene expression level might have on the susceptibility to infection raises some concerns about the final biological relevance of these models. Here we report that endpoint titration of a sheep scrapie isolate in sheep and in mice overexpressing the ovine PrP results in similar estimates of the infectious titer.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Gene Expression
/
Prion Diseases
/
PrPSc Proteins
/
Disease Susceptibility
Type of study:
Diagnostic_studies
Limits:
Animals
Language:
En
Journal:
J Virol
Year:
2014
Type:
Article
Affiliation country:
France