Expression level and subcellular localization of heme oxygenase-1 modulates its cytoprotective properties in response to lung injury: a mouse model.

Namba, Fumihiko; Go, Hayato; Murphy, Jennifer A; La, Ping; Yang, Guang; Sengupta, Shaon; Fernando, Amal P; Yohannes, Mekdes; Biswas, Chhanda; Wehrli, Suzanne L; Dennery, Phyllis A

Namba, Fumihiko; Go, Hayato; Murphy, Jennifer A; La, Ping; Yang, Guang; Sengupta, Shaon; Fernando, Amal P; Yohannes, Mekdes; Biswas, Chhanda; Wehrli, Suzanne L; Dennery, Phyllis A.

Affiliation

Namba F; Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.
Go H; Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.
Murphy JA; Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.
La P; Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.
Yang G; Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.
Sengupta S; Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.
Fernando AP; Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.
Yohannes M; Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.
Biswas C; Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America; Department of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.
Wehrli SL; Small Animal Core, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America.
Dennery PA; Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America; Department of Pediatrics, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America.

PLoS One ; 9(3): e90936, 2014.

Article in En | MEDLINE | ID: mdl-24599172

Subject(s)

Cytoprotection; Heme Oxygenase-1/metabolism; Lung Injury/enzymology; Lung Injury/pathology; Animals; Animals, Newborn; Apoptosis; Carcinogenesis/pathology; Cell Proliferation; DNA/metabolism; DNA Damage; Disease Models, Animal; Epithelial Cells/enzymology; Epithelial Cells/pathology; Humans; Hydrolysis; Hyperoxia/enzymology; Hyperoxia/pathology; Hyperoxia/physiopathology; Lung/enzymology; Lung/pathology; Lung/physiopathology; Lung Injury/physiopathology; Magnetic Resonance Imaging; Mice; Mice, Transgenic; Oxidation-Reduction; Oxidative Stress; Poly Adenosine Diphosphate Ribose/metabolism; Poly(ADP-ribose) Polymerases/metabolism; Pulmonary Alveoli/enzymology; Pulmonary Alveoli/pathology; Pulmonary Alveoli/physiopathology; Respiratory Function Tests; Subcellular Fractions/drug effects; Subcellular Fractions/enzymology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cytoprotection / Heme Oxygenase-1 / Lung Injury Type of study: Prognostic_studies Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2014 Type: Article Affiliation country: United States

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