Fine particulate matter results in hemodynamic changes in subjects with blunted nocturnal blood pressure dipping.
Environ Res
; 131: 1-5, 2014 May.
Article
in En
| MEDLINE
| ID: mdl-24607658
ABSTRACT
Particulate matter with aerodynamic diameter of <2.5 µm (PM2.5) is associated with blood pressure and hemodynamic changes. Blunted nocturnal blood pressure dipping is a major risk factor for cardiovascular events; limited information is available on whether PM2.5 exposure-related hemodynamic changes vary with day-night blood pressure circadian rhythms. In this study, we enrolled 161 subjects and monitored the changes in ambulatory blood pressure and hemodynamics for 24h. The day-night blood pressure and cardiovascular metrics were calculated according to the sleep-wake cycles logged in the subject׳s diary. The effects of PM2.5 exposure on blood pressure and hemodynamic changes were analyzed using generalized linear mixed-effect model. After adjusting for potential confounders, a 10-µg/m(3) increase in PM2.5 was associated with 1.0 mmHg [95% confidence interval (CI) 0.2-1.8 mmHg] narrowing in the pulse pressure, 3.1% (95% CI 1.4-4.8%) decrease in the maximum rate of left ventricular pressure rise, and 3.6% (95% CI 1.6-5.7%) increase in systemic vascular resistance among 79 subjects with nocturnal blood pressure dip of <10%. In contrast, PM2.5 was not associated with any changes in cardiovascular metrics among 82 subjects with nocturnal blood pressure dip of ≥10%. Our findings demonstrate that short-term exposure to PM2.5 contributes to pulse pressure narrowing along with cardiac and vasomotor dysfunctions in subjects with nocturnal blood pressure dip of <10%.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Blood Pressure
/
Cardiovascular Diseases
/
Circadian Rhythm
/
Particulate Matter
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Environ Res
Year:
2014
Type:
Article
Affiliation country:
Taiwan