Angiotensin-II type 1 receptor-mediated Janus kinase 2 activation induces liver fibrosis.

Granzow, Michaela; Schierwagen, Robert; Klein, Sabine; Kowallick, Benita; Huss, Sebastian; Linhart, Markus; Mazar, Irela G Reza; Görtzen, Jan; Vogt, Annabelle; Schildberg, Frank A; Gonzalez-Carmona, Maria A; Wojtalla, Alexandra; Krämer, Benjamin; Nattermann, Jacob; Siegmund, Sören V; Werner, Nikos; Fürst, Dieter O; Laleman, Wim; Knolle, Percy; Shah, Vijay H; Sauerbruch, Tilman; Trebicka, Jonel

Granzow, Michaela; Schierwagen, Robert; Klein, Sabine; Kowallick, Benita; Huss, Sebastian; Linhart, Markus; Mazar, Irela G Reza; Görtzen, Jan; Vogt, Annabelle; Schildberg, Frank A; Gonzalez-Carmona, Maria A; Wojtalla, Alexandra; Krämer, Benjamin; Nattermann, Jacob; Siegmund, Sören V; Werner, Nikos; Fürst, Dieter O; Laleman, Wim; Knolle, Percy; Shah, Vijay H; Sauerbruch, Tilman; Trebicka, Jonel.

Affiliation

Granzow M; Department of Internal Medicine I, University of Bonn, Bonn, Germany.

Hepatology ; 60(1): 334-48, 2014 Jul.

Article in En | MEDLINE | ID: mdl-24619965

Subject(s)

Chemical and Drug Induced Liver Injury/metabolism; Janus Kinase 2/metabolism; Liver Cirrhosis/metabolism; Receptor, Angiotensin, Type 1/metabolism; Angiotensin II/toxicity; Animals; Bile Ducts; Carbon Tetrachloride/toxicity; Disease Models, Animal; Hepatic Stellate Cells/metabolism; Humans; Ligation; Mice; Mice, Inbred C57BL; Mice, Knockout; Myofibroblasts/metabolism; Phosphorylation/physiology; Rats; Rats, Sprague-Dawley; Signal Transduction/physiology; Thioacetamide/toxicity

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptor, Angiotensin, Type 1 / Janus Kinase 2 / Chemical and Drug Induced Liver Injury / Liver Cirrhosis Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Hepatology Year: 2014 Type: Article Affiliation country: Germany

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