Assessment of the abuse liability of a dual orexin receptor antagonist: a crossover study of almorexant and zolpidem in recreational drug users.

Cruz, Hans G; Hoever, Petra; Chakraborty, Bijan; Schoedel, Kerri; Sellers, Edward M; Dingemanse, Jasper

Cruz, Hans G; Hoever, Petra; Chakraborty, Bijan; Schoedel, Kerri; Sellers, Edward M; Dingemanse, Jasper.

Affiliation

Cruz HG; Actelion Pharmaceuticals Ltd, Clinical Pharmacology, Gewerbestrasse 16, 4123, Allschwil, Switzerland.

CNS Drugs ; 28(4): 361-72, 2014 Apr.

Article in En | MEDLINE | ID: mdl-24627301

Subject(s)

Acetamides/administration & dosage; Hypnotics and Sedatives/administration & dosage; Illicit Drugs/adverse effects; Isoquinolines/administration & dosage; Orexin Receptor Antagonists; Pyridines/administration & dosage; Acetamides/pharmacokinetics; Adolescent; Adult; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Hypnotics and Sedatives/pharmacokinetics; Isoquinolines/pharmacokinetics; Male; Middle Aged; Orexin Receptors/metabolism; Pyridines/pharmacokinetics; Substance-Related Disorders/diagnosis; Substance-Related Disorders/metabolism; Young Adult; Zolpidem

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Illicit Drugs / Orexin Receptor Antagonists / Hypnotics and Sedatives / Isoquinolines / Acetamides Type of study: Clinical_trials / Diagnostic_studies Limits: Adolescent / Adult / Female / Humans / Male / Middle aged Language: En Journal: CNS Drugs Journal subject: FARMACOLOGIA / NEUROLOGIA / TERAPIA POR MEDICAMENTOS Year: 2014 Type: Article Affiliation country: Switzerland

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