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Pyrazoles as non-classical bioisosteres in prolylcarboxypeptidase (PrCP) inhibitors.
Graham, Thomas H; Shu, Min; Verras, Andreas; Chen, Qing; Garcia-Calvo, Margarita; Li, Xiaohua; Lisnock, JeanMarie; Tong, Xinchun; Tung, Elaine C; Wiltsie, Judyann; Hale, Jeffrey J; Pinto, Shirly; Shen, Dong-Ming.
Affiliation
  • Graham TH; Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065-0900, USA. Electronic address: thomas.graham@merck.com.
  • Shu M; Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065-0900, USA.
  • Verras A; Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065-0900, USA.
  • Chen Q; Department of Drug Metabolism, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065-0900, USA.
  • Garcia-Calvo M; Department of Metabolic Disorders, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065-0900, USA.
  • Li X; Department of Drug Metabolism, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065-0900, USA.
  • Lisnock J; Department of In Vitro Sciences, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065-0900, USA.
  • Tong X; Department of Drug Metabolism, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065-0900, USA.
  • Tung EC; Department of Drug Metabolism, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065-0900, USA.
  • Wiltsie J; Department of In Vitro Sciences, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065-0900, USA.
  • Hale JJ; Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065-0900, USA.
  • Pinto S; Department of Metabolic Disorders, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065-0900, USA.
  • Shen DM; Department of Medicinal Chemistry, Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065-0900, USA.
Bioorg Med Chem Lett ; 24(7): 1657-60, 2014 Apr 01.
Article in En | MEDLINE | ID: mdl-24636945
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Carboxypeptidases / Enzyme Inhibitors Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2014 Type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrazoles / Carboxypeptidases / Enzyme Inhibitors Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Journal subject: BIOQUIMICA / QUIMICA Year: 2014 Type: Article