Gene therapy for neuropathic pain by silencing of TNF-&#945; expression with lentiviral vectors targeting the dorsal root ganglion in mice.

Ogawa, Nobuhiro; Kawai, Hiromichi; Terashima, Tomoya; Kojima, Hideto; Oka, Kazuhiro; Chan, Lawrence; Maegawa, Hiroshi

Gene therapy for neuropathic pain by silencing of TNF-α expression with lentiviral vectors targeting the dorsal root ganglion in mice.

Ogawa, Nobuhiro; Kawai, Hiromichi; Terashima, Tomoya; Kojima, Hideto; Oka, Kazuhiro; Chan, Lawrence; Maegawa, Hiroshi.

Affiliation

Ogawa N; Department of Medicine, Molecular Genetics in Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan.
Kawai H; Department of Medicine, Molecular Genetics in Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan.
Terashima T; Department of Medicine, Molecular Genetics in Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan.
Kojima H; Department of Molecular Genetics in Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan.
Oka K; Departments of Medicine and Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America.
Chan L; Departments of Medicine and Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America.
Maegawa H; Department of Medicine, Molecular Genetics in Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan.

PLoS One ; 9(3): e92073, 2014.

Article in En | MEDLINE | ID: mdl-24642694

Subject(s)

Genetic Therapy/methods; Lentivirus/genetics; Neuralgia/therapy; RNA, Messenger/antagonists & inhibitors; RNA, Small Interfering/genetics; Tumor Necrosis Factor-alpha/antagonists & inhibitors; Activating Transcription Factor 3/genetics; Activating Transcription Factor 3/metabolism; Animals; Cell Death/genetics; Disease Models, Animal; Ganglia, Spinal/injuries; Ganglia, Spinal/metabolism; Gene Expression Regulation; Gene Silencing; Genetic Vectors; Interleukin-6/antagonists & inhibitors; Interleukin-6/genetics; Interleukin-6/metabolism; Male; Mice; Mice, Inbred C57BL; Neuralgia/genetics; Neuralgia/metabolism; Neuralgia/pathology; Neurons/metabolism; Neurons/pathology; Neuropeptide Y/antagonists & inhibitors; Neuropeptide Y/genetics; Neuropeptide Y/metabolism; RNA, Messenger/genetics; RNA, Messenger/metabolism; RNA, Small Interfering/metabolism; Signal Transduction; Spinal Cord Injuries; Tumor Necrosis Factor-alpha/genetics; Tumor Necrosis Factor-alpha/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA, Messenger / Genetic Therapy / Tumor Necrosis Factor-alpha / Lentivirus / RNA, Small Interfering / Neuralgia Type of study: Prognostic_studies Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2014 Type: Article Affiliation country: Japan

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