MicroRNA-9 and microRNA-326 regulate human dopamine D2 receptor expression, and the microRNA-mediated expression regulation is altered by a genetic variant.

Shi, Sandra; Leites, Catherine; He, Deli; Schwartz, Daniel; Moy, Winton; Shi, Jianxin; Duan, Jubao

Shi, Sandra; Leites, Catherine; He, Deli; Schwartz, Daniel; Moy, Winton; Shi, Jianxin; Duan, Jubao.

Affiliation

Shi S; From the Department of Psychiatry and Behavioral Sciences, NorthShore University HealthSystem, Evanston, Illinois 60201.

J Biol Chem ; 289(19): 13434-44, 2014 May 09.

Article in En | MEDLINE | ID: mdl-24675081

Subject(s)

Dopaminergic Neurons/metabolism; Gene Expression Regulation; MicroRNAs/metabolism; Receptors, Dopamine D2/biosynthesis; Schizophrenia/metabolism; Animals; CHO Cells; Cricetinae; Cricetulus; Dopaminergic Neurons/pathology; Humans; Induced Pluripotent Stem Cells/metabolism; Induced Pluripotent Stem Cells/pathology; MicroRNAs/genetics; RNA, Messenger/genetics; RNA, Messenger/metabolism; Receptors, Dopamine D2/genetics; Schizophrenia/drug therapy; Schizophrenia/genetics; Schizophrenia/pathology

Key words

DRD2; Dopamine Receptors; Gene Expression; Gene Regulation; Genetic Polymorphism; MicroRNA; Pharmacogenetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Schizophrenia / Gene Expression Regulation / Receptors, Dopamine D2 / MicroRNAs / Dopaminergic Neurons Limits: Animals / Humans Language: En Journal: J Biol Chem Year: 2014 Type: Article

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