Investigation of evolved paraoxonase-1 variants for prevention of organophosphorous pesticide compound intoxication.

Mata, David G; Rezk, Peter E; Sabnekar, Praveena; Cerasoli, Douglas M; Chilukuri, Nageswararao

Mata, David G; Rezk, Peter E; Sabnekar, Praveena; Cerasoli, Douglas M; Chilukuri, Nageswararao.

Affiliation

Mata DG; Physiology and Immunology Branch, Research Division, United States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, Maryland.

J Pharmacol Exp Ther ; 349(3): 549-58, 2014 Jun.

Article in En | MEDLINE | ID: mdl-24706983

Subject(s)

Aryldialkylphosphatase/genetics; Aryldialkylphosphatase/metabolism; Gene Transfer Techniques; Genetic Variation; Organophosphate Poisoning/prevention & control; Pesticides/toxicity; Adenoviridae/genetics; Animals; Aryldialkylphosphatase/blood; Biocatalysis; Escherichia coli/genetics; Genetic Vectors; HEK293 Cells; Humans; Lethal Dose 50; Male; Mice; Organophosphate Poisoning/enzymology; Pesticides/pharmacokinetics; Protein Engineering

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pesticides / Genetic Variation / Gene Transfer Techniques / Aryldialkylphosphatase / Organophosphate Poisoning Limits: Animals / Humans / Male Language: En Journal: J Pharmacol Exp Ther Year: 2014 Type: Article

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