Reversal of dabigatran-induced bleeding by coagulation factor concentrates in a rat-tail bleeding model and lack of effect on assays of coagulation.

van Ryn, Joanne; Schurer, Johanna; Kink-Eiband, Monika; Clemens, Andreas

van Ryn, Joanne; Schurer, Johanna; Kink-Eiband, Monika; Clemens, Andreas.

Affiliation

van Ryn J; From the Department of CardioMetabolic Disease Research, Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany (J.v.R., J.S., M.K.-E.); and Department of Global Clinical Development and Medical Affairs, Boehringer Ingelheim Pharma GmbH & Co. KG, Ingelheim am Rhein, Germany (A.C.).

Anesthesiology ; 120(6): 1429-40, 2014 Jun.

Article in En | MEDLINE | ID: mdl-24714118

Subject(s)

Benzimidazoles/toxicity; Blood Coagulation Factors/therapeutic use; Blood Coagulation/drug effects; Disease Models, Animal; Hemorrhage/chemically induced; Hemorrhage/drug therapy; Pyridines/toxicity; Animals; Blood Coagulation/physiology; Blood Coagulation Factors/pharmacology; Dabigatran; Humans; Rats; Rats, Wistar; Tail/blood supply; Treatment Outcome

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyridines / Benzimidazoles / Blood Coagulation / Blood Coagulation Factors / Disease Models, Animal / Hemorrhage Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Anesthesiology Year: 2014 Type: Article

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