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Identification of new 4-N-substituted 6-aryl-7H-pyrrolo[2,3-d]pyrimidine-4-amines as highly potent EGFR-TK inhibitors with Src-family activity.
Kaspersen, Svein Jacob; Han, Jin; Nørsett, Kristin G; Rydså, Line; Kjøbli, Eli; Bugge, Steffen; Bjørkøy, Geir; Sundby, Eirik; Hoff, Bård Helge.
Affiliation
  • Kaspersen SJ; Norwegian University of Science and Technology, Department of Chemistry, Høgskoleringen 5, NO-7491 Trondheim, Norway. Electronic address: Svein.jacob.kaspersen@chem.ntnu.no.
  • Han J; Norwegian University of Science and Technology, Department of Chemistry, Høgskoleringen 5, NO-7491 Trondheim, Norway; Sør-Trøndelag University College, E.C. Dahls gt. 2, NO-7004 Trondheim, Norway. Electronic address: Jin.han@chem.ntnu.no.
  • Nørsett KG; Norwegian University of Science and Technology, Department of Cancer Research and Molecular Medicine, Prinsesse Kristinas gt. 1, NO-7006 Trondheim, Norway. Electronic address: kristin.norsett@ntnu.no.
  • Rydså L; Norwegian University of Science and Technology, Department of Chemistry, Høgskoleringen 5, NO-7491 Trondheim, Norway. Electronic address: line.rydsa@sintef.no.
  • Kjøbli E; Sør-Trøndelag University College, Erling Skjalgssons gt. 1, NO-7004 Trondheim, Norway. Electronic address: eli.kjobli@hist.no.
  • Bugge S; Norwegian University of Science and Technology, Department of Chemistry, Høgskoleringen 5, NO-7491 Trondheim, Norway. Electronic address: steffen.bugge@chem.ntnu.no.
  • Bjørkøy G; Norwegian University of Science and Technology, Department of Cancer Research and Molecular Medicine, Prinsesse Kristinas gt. 1, NO-7006 Trondheim, Norway; Sør-Trøndelag University College, Erling Skjalgssons gt. 1, NO-7004 Trondheim, Norway. Electronic address: geir.bjorkoy@hist.no.
  • Sundby E; Sør-Trøndelag University College, E.C. Dahls gt. 2, NO-7004 Trondheim, Norway. Electronic address: Eirik.Sundby@hist.no.
  • Hoff BH; Norwegian University of Science and Technology, Department of Chemistry, Høgskoleringen 5, NO-7491 Trondheim, Norway. Electronic address: bard.helge.hoff@chem.ntnu.no.
Eur J Pharm Sci ; 59: 69-82, 2014 Aug 01.
Article in En | MEDLINE | ID: mdl-24769040
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Pyrroles / Src-Family Kinases / Protein Kinase Inhibitors / ErbB Receptors / Amines Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Eur J Pharm Sci Journal subject: FARMACIA / FARMACOLOGIA / QUIMICA Year: 2014 Type: Article
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pyrimidines / Pyrroles / Src-Family Kinases / Protein Kinase Inhibitors / ErbB Receptors / Amines Type of study: Diagnostic_studies / Prognostic_studies Limits: Humans Language: En Journal: Eur J Pharm Sci Journal subject: FARMACIA / FARMACOLOGIA / QUIMICA Year: 2014 Type: Article