Eszopiclone and dexmedetomidine depress ventilation in obese rats with features of metabolic syndrome.

Filbey, William A; Sanford, David T; Baghdoyan, Helen A; Koch, Lauren G; Britton, Steven L; Lydic, Ralph

Filbey, William A; Sanford, David T; Baghdoyan, Helen A; Koch, Lauren G; Britton, Steven L; Lydic, Ralph.

Affiliation

Filbey WA; Department of Anesthesiology, University of Michigan, Ann Arbor, MI.
Sanford DT; Department of Anesthesiology, University of Michigan, Ann Arbor, MI.
Baghdoyan HA; Department of Anesthesiology, University of Michigan, Ann Arbor, MI.
Koch LG; Department of Anesthesiology, University of Michigan, Ann Arbor, MI.
Britton SL; Department of Anesthesiology, University of Michigan, Ann Arbor, MI.
Lydic R; Department of Anesthesiology, University of Michigan, Ann Arbor, MI.

Sleep ; 37(5): 871-80, 2014 May 01.

Article in En | MEDLINE | ID: mdl-24790265

Subject(s)

Azabicyclo Compounds/pharmacology; Dexmedetomidine/pharmacology; Metabolic Syndrome/complications; Metabolic Syndrome/metabolism; Obesity/complications; Obesity/physiopathology; Piperazines/pharmacology; Respiration/drug effects; Adrenergic alpha-2 Receptor Agonists/pharmacology; Animals; Azabicyclo Compounds/adverse effects; Body Weight/drug effects; Dexmedetomidine/adverse effects; Eszopiclone; Hypercapnia/metabolism; Hypnotics and Sedatives/adverse effects; Hypnotics and Sedatives/pharmacology; Hypoxia/metabolism; Piperazines/adverse effects; Rats; Respiratory Mechanics/drug effects; Thinness/metabolism; Tidal Volume

Key words

alpha-2 adrenergic agonist; benzodiazepine site agonist; metabolic syndrome; non-benzodiazepine; sedatives

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Piperazines / Respiration / Dexmedetomidine / Metabolic Syndrome / Azabicyclo Compounds / Obesity Type of study: Prognostic_studies Limits: Animals Language: En Journal: Sleep Year: 2014 Type: Article

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