Deficiency of the NR4A orphan nuclear receptor NOR1 in hematopoietic stem cells accelerates atherosclerosis.

Qing, Hua; Liu, Yi; Zhao, Yue; Aono, Jun; Jones, Karrie L; Heywood, Elizabeth B; Howatt, Deborah; Binkley, Cassi M; Daugherty, Alan; Liang, Ying; Bruemmer, Dennis

Qing, Hua; Liu, Yi; Zhao, Yue; Aono, Jun; Jones, Karrie L; Heywood, Elizabeth B; Howatt, Deborah; Binkley, Cassi M; Daugherty, Alan; Liang, Ying; Bruemmer, Dennis.

Affiliation

Qing H; Division of Cardiovascular Medicine, Gill Heart Institute, and Saha Cardiovascular Research Center, Chongqing, People's Republic of China; Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.

Stem Cells ; 32(9): 2419-29, 2014 Sep.

Article in En | MEDLINE | ID: mdl-24806827

Subject(s)

DNA-Binding Proteins/deficiency; Hematopoietic Stem Cells/metabolism; Monocytes/metabolism; Nerve Tissue Proteins/deficiency; Plaque, Atherosclerotic/metabolism; Plaque, Atherosclerotic/pathology; Receptors, Steroid/deficiency; Receptors, Thyroid Hormone/deficiency; Animals; Cell Proliferation/physiology; Cells, Cultured; DNA-Binding Proteins/genetics; DNA-Binding Proteins/metabolism; Female; HEK293 Cells; Hematopoietic Stem Cells/cytology; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/metabolism; Plaque, Atherosclerotic/genetics; Receptors, Steroid/genetics; Receptors, Steroid/metabolism; Receptors, Thyroid Hormone/genetics; Receptors, Thyroid Hormone/metabolism; Transfection

Key words

Atherosclerosis; Macrophage and dendritic progenitors; Monocyte; Nuclear receptor

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Receptors, Thyroid Hormone / Hematopoietic Stem Cells / Monocytes / Receptors, Steroid / DNA-Binding Proteins / Plaque, Atherosclerotic / Nerve Tissue Proteins Type of study: Prognostic_studies Limits: Animals / Female / Humans / Male Language: En Journal: Stem Cells Year: 2014 Type: Article

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