Altered signaling in the G1 phase deregulates chondrocyte growth in a mouse model with proteoglycan undersulfation.

De Leonardis, Fabio; Monti, Luca; Gualeni, Benedetta; Tenni, Ruggero; Forlino, Antonella; Rossi, Antonio

De Leonardis, Fabio; Monti, Luca; Gualeni, Benedetta; Tenni, Ruggero; Forlino, Antonella; Rossi, Antonio.

Affiliation

De Leonardis F; Department of Molecular Medicine, Unit of Biochemistry, University of Pavia, Pavia, Italy.

J Cell Biochem ; 115(10): 1779-86, 2014 Oct.

Article in En | MEDLINE | ID: mdl-24820054

Subject(s)

Bone Development/genetics; Chondrocytes/metabolism; Cyclin D1/biosynthesis; E2F Transcription Factors/antagonists & inhibitors; Retinoblastoma-Like Protein p130/metabolism; Animals; Bone Diseases/genetics; Bone and Bones/metabolism; Bone and Bones/pathology; Cartilage, Articular/metabolism; Cartilage, Articular/pathology; Cell Differentiation/genetics; Cell Proliferation/genetics; Chondroitin Sulfate Proteoglycans/metabolism; Extracellular Matrix/pathology; G1 Phase/genetics; Gene Knock-In Techniques; Growth Plate/metabolism; Hedgehog Proteins/metabolism; Mice; Mice, Inbred C57BL; Phosphorylation; Signal Transduction/genetics; Smad3 Protein/biosynthesis; Transforming Growth Factor beta/metabolism; Wnt Signaling Pathway; beta Catenin/metabolism

Key words

CELL CYCLE; GROWTH PLATE; PROTEOGLYCAN SULFATION; SKELETAL DYSPLASIA; WNT PATHWAY

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bone Development / Chondrocytes / Cyclin D1 / Retinoblastoma-Like Protein p130 / E2F Transcription Factors Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Cell Biochem Year: 2014 Type: Article Affiliation country: Italy

Fulltext

XML

PubMed Links

Search on Google