Measles vaccination in the presence or absence of maternal measles antibody: impact on child survival.
Clin Infect Dis
; 59(4): 484-92, 2014 Aug 15.
Article
in En
| MEDLINE
| ID: mdl-24829213
ABSTRACT
BACKGROUND:
Measles vaccine (MV) has a greater effect on child survival when administered in early infancy, when maternal antibody may still be present.METHODS:
To test whether MV has a greater effect on overall survival if given in the presence of maternal measles antibody, we reanalyzed data from 2 previously published randomized trials of a 2-dose schedule with MV given at 4-6 months and at 9 months of age. In both trials antibody levels had been measured before early measles vaccination.RESULTS:
In trial I (1993-1995), the mortality rate was 0.0 per 1000 person-years among children vaccinated with MV in the presence of maternal antibody and 32.3 per 1000 person-years without maternal antibody (mortality rate ratio [MRR], 0.0; 95% confidence interval [CI], 0-.52). In trial II (2003-2007), the mortality rate was 4.2 per 1000 person-years among children vaccinated in presence of maternal measles antibody and 14.5 per 1000 person-years without measles antibody (MRR, 0.29; 95% CI, .09-.91). Possible confounding factors did not explain the difference. In a combined analysis, children who had measles antibody detected when they received their first dose of MV at 4-6 months of age had lower mortality than children with no maternal antibody, the MRR being 0.22 (95% CI, .07-.64) between 4-6 months and 5 years.CONCLUSIONS:
Child mortality in low-income countries may be reduced by vaccinating against measles in the presence of maternal antibody, using a 2-dose schedule with the first dose at 4-6 months (earlier than currently recommended) and a booster dose at 9-12 months of age. CLINICAL TRIALS REGISTRATION NCT00168558.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Measles Vaccine
/
Vaccination
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Immunity, Maternally-Acquired
/
Measles
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Antibodies, Viral
Type of study:
Clinical_trials
Limits:
Child, preschool
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Female
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Humans
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Infant
/
Male
Language:
En
Journal:
Clin Infect Dis
Journal subject:
DOENCAS TRANSMISSIVEIS
Year:
2014
Type:
Article