Enhanced toxicity of cisplatin with chemosensitizer phenethyl isothiocyanate toward non-small cell lung cancer cells when delivered in liposomal nanoparticles.

Yang, Yu-Tsai; Shi, Yi; Jay, Michael; Di Pasqua, Anthony J

Yang, Yu-Tsai; Shi, Yi; Jay, Michael; Di Pasqua, Anthony J.

Affiliation

Yang YT; Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill , Chapel Hill, North Carolina 27599, United States.

Chem Res Toxicol ; 27(6): 946-8, 2014 Jun 16.

Article in En | MEDLINE | ID: mdl-24836554

Subject(s)

Antineoplastic Agents/pharmacology; Carcinoma, Non-Small-Cell Lung/drug therapy; Cisplatin/pharmacology; Drug Delivery Systems; Isothiocyanates/pharmacology; Lung Neoplasms/drug therapy; Nanoparticles/administration & dosage; Antineoplastic Agents/administration & dosage; Carcinoma, Non-Small-Cell Lung/pathology; Cell Proliferation/drug effects; Cell Survival/drug effects; Cisplatin/administration & dosage; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Isothiocyanates/administration & dosage; Liposomes/administration & dosage; Liposomes/chemistry; Lung Neoplasms/pathology; Molecular Structure; Nanoparticles/chemistry; Particle Size; Structure-Activity Relationship; Surface Properties

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cisplatin / Drug Delivery Systems / Isothiocyanates / Carcinoma, Non-Small-Cell Lung / Nanoparticles / Lung Neoplasms / Antineoplastic Agents Limits: Humans Language: En Journal: Chem Res Toxicol Journal subject: TOXICOLOGIA Year: 2014 Type: Article Affiliation country: United States

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