FOXO1-mediated activation of Akt plays a critical role in vascular homeostasis.

Dharaneeswaran, Harita; Abid, Md Ruhul; Yuan, Lei; Dupuis, Dylan; Beeler, David; Spokes, Katherine C; Janes, Lauren; Sciuto, Tracey; Kang, Peter M; Jaminet, Shou-Ching S; Dvorak, Ann; Grant, Marianne A; Regan, Erzsébet Ravasz; Aird, William C

Dharaneeswaran, Harita; Abid, Md Ruhul; Yuan, Lei; Dupuis, Dylan; Beeler, David; Spokes, Katherine C; Janes, Lauren; Sciuto, Tracey; Kang, Peter M; Jaminet, Shou-Ching S; Dvorak, Ann; Grant, Marianne A; Regan, Erzsébet Ravasz; Aird, William C.

Affiliation

Dharaneeswaran H; Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston MA 02215.
Abid MR; Department of Medicine, Beth Israel Deaconess Medical Center, Boston MA 02215.
Yuan L; Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston MA 02215.
Dupuis D; Department of Medicine, Beth Israel Deaconess Medical Center, Boston MA 02215.
Beeler D; Warren Alpert Medical School of Brown University, Cardiovascular Research Center, Rhode Island Hospital, Providence, RI 02903.
Spokes KC; Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston MA 02215.
Janes L; Department of Medicine, Beth Israel Deaconess Medical Center, Boston MA 02215.
Sciuto T; Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston MA 02215.
Kang PM; Department of Medicine, Beth Israel Deaconess Medical Center, Boston MA 02215.
Jaminet SS; Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston MA 02215.
Dvorak A; Department of Medicine, Beth Israel Deaconess Medical Center, Boston MA 02215.
Grant MA; Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston MA 02215.
Regan ER; Department of Medicine, Beth Israel Deaconess Medical Center, Boston MA 02215.
Aird WC; Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston MA 02215.

Circ Res ; 115(2): 238-251, 2014 Jul 07.

Article in En | MEDLINE | ID: mdl-24874427

Subject(s)

Endothelial Cells/metabolism; Forkhead Transcription Factors/physiology; Heart Failure/genetics; Multiprotein Complexes/physiology; Neovascularization, Physiologic/physiology; Proto-Oncogene Proteins c-akt/physiology; TOR Serine-Threonine Kinases/physiology; Animals; Enzyme Induction; Forkhead Box Protein O1; Forkhead Box Protein O3; Forkhead Transcription Factors/antagonists & inhibitors; Forkhead Transcription Factors/deficiency; Forkhead Transcription Factors/genetics; Heart Failure/physiopathology; Homeostasis; Human Umbilical Vein Endothelial Cells; Mechanistic Target of Rapamycin Complex 1; Mice; Mice, Knockout; Mice, Transgenic; Neovascularization, Physiologic/genetics; Nitric Oxide Synthase Type III/biosynthesis; Nitric Oxide Synthase Type III/genetics; Organ Specificity; RNA, Small Interfering/pharmacology; Recombinant Fusion Proteins; Signal Transduction/physiology; Yolk Sac/blood supply

Key words

FoxO1 protein, human; angiogenesis; endothelial cells; mice, transgenic; transcription factors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neovascularization, Physiologic / Endothelial Cells / Multiprotein Complexes / Proto-Oncogene Proteins c-akt / Forkhead Transcription Factors / TOR Serine-Threonine Kinases / Heart Failure Limits: Animals Language: En Journal: Circ Res Year: 2014 Type: Article

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