EGFR mediates docetaxel resistance in human castration-resistant prostate cancer through the Akt-dependent expression of ABCB1 (MDR1).

Hour, Tzyh-Chyuan; Chung, Shiu-Dong; Kang, Wang-Yi; Lin, Ying-Chu; Chuang, Shu-Ju; Huang, A-Mei; Wu, Wen-Jeng; Huang, Shu-Pin; Huang, Chao-Yuan; Pu, Yeong-Shiau

Hour, Tzyh-Chyuan; Chung, Shiu-Dong; Kang, Wang-Yi; Lin, Ying-Chu; Chuang, Shu-Ju; Huang, A-Mei; Wu, Wen-Jeng; Huang, Shu-Pin; Huang, Chao-Yuan; Pu, Yeong-Shiau.

Affiliation

Hour TC; Institute of Biochemistry, Kaohsiung Medical University, Kaohsiung, Taiwan.

Arch Toxicol ; 89(4): 591-605, 2015 Apr.

Article in En | MEDLINE | ID: mdl-24888374

Subject(s)

Antineoplastic Agents/therapeutic use; Drug Resistance, Neoplasm; ErbB Receptors/genetics; Prostatic Neoplasms, Castration-Resistant/drug therapy; Taxoids/therapeutic use; ATP Binding Cassette Transporter, Subfamily B/genetics; ATP Binding Cassette Transporter, Subfamily B/metabolism; Animals; Antineoplastic Agents/administration & dosage; Cell Line, Tumor; Cell Survival/drug effects; Docetaxel; Drug Resistance, Neoplasm/genetics; ErbB Receptors/antagonists & inhibitors; ErbB Receptors/metabolism; Humans; Male; Mice, Inbred BALB C; Prostatic Neoplasms, Castration-Resistant/genetics; Prostatic Neoplasms, Castration-Resistant/metabolism; Prostatic Neoplasms, Castration-Resistant/pathology; Proto-Oncogene Proteins c-akt/metabolism; RNA, Small Interfering/genetics; Signal Transduction; Taxoids/administration & dosage; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Resistance, Neoplasm / Taxoids / Prostatic Neoplasms, Castration-Resistant / ErbB Receptors / Antineoplastic Agents Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: Arch Toxicol Year: 2015 Type: Article Affiliation country: Taiwan

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