Histamine H1-receptor antagonists against Leishmania (L.) infantum: an in vitro and in vivo evaluation using phosphatidylserine-liposomes.

Pinto, Erika G; da Costa-Silva, Thais A; Tempone, Andre Gustavo

Pinto, Erika G; da Costa-Silva, Thais A; Tempone, Andre Gustavo.

Affiliation

Pinto EG; Center for Parasitology and Mycology, Instituto Adolfo Lutz, Av. Dr. Arnaldo, 351, 01246-900, São Paulo SP, Brazil; Instituto de Medicina Tropical de São Paulo, Universidade de São Paulo, Av. Dr. Enéas de Carvalho Aguiar, 470, 05403-000, São Paulo SP, Brazil.
da Costa-Silva TA; Center for Parasitology and Mycology, Instituto Adolfo Lutz, Av. Dr. Arnaldo, 351, 01246-900, São Paulo SP, Brazil.
Tempone AG; Center for Parasitology and Mycology, Instituto Adolfo Lutz, Av. Dr. Arnaldo, 351, 01246-900, São Paulo SP, Brazil. Electronic address: atempone@usp.br.

Acta Trop ; 137: 206-10, 2014 Sep.

Article in En | MEDLINE | ID: mdl-24905294

Subject(s)

Antiprotozoal Agents/pharmacology; Antiprotozoal Agents/therapeutic use; Histamine H1 Antagonists/pharmacology; Histamine H1 Antagonists/therapeutic use; Leishmania infantum/drug effects; Leishmaniasis, Visceral/drug therapy; Leishmaniasis/drug therapy; Animals; Antiprotozoal Agents/toxicity; Cell Survival/drug effects; Disease Models, Animal; Drug Repositioning; Histamine H1 Antagonists/toxicity; Humans; Inhibitory Concentration 50; Leishmania infantum/physiology; Male; Mesocricetus; Mice, Inbred BALB C; Parasite Load; Survival Analysis; Treatment Outcome

Key words

Cinnarizine; H1 antagonist; Histamine; Leishmania; Liposomes; Therapy

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Leishmaniasis / Leishmania infantum / Histamine H1 Antagonists / Leishmaniasis, Visceral / Antiprotozoal Agents Limits: Animals / Humans / Male Language: En Journal: Acta Trop Year: 2014 Type: Article Affiliation country: Brazil

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